Welcome everyone to Episode 101 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter.
The Science Round Up
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This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- Some bacteria shield tumor cells against chemo drugs.
- Change your diet, change your microbiota.
- Mars simulation concludes.
- North American Ash on brink of extinction.
- First genetically engineered blood stem cell clinical trial launched.
- Antibodies to replace genes for IPS reprogramming
- Stem cell communication.
The interview with Dr. Jack Parent
In the interview portion of this episode, STEMCELL Technologies announces a new product called CloneR™ which makes genome editing easier. Here are the highlights:
- Use CloneR from STEMCELL Technologies to increase the cloning efficiency of human pluripotent stem cells (hPSCs).
- Genome editing of hPSCs relies heavily on the survival of single cells to establish clonal cell lines.
- CloneR is a medium supplement that works with mTeSR1or TeSR-E8.
- Unlike current methods, CloneR enables the robust generation of clonal cell lines without single-cell adaptation, thus minimizing the risk of acquiring genetic abnormalities.
- Learn more at stemcell.com/cloner.
For the interview portion of the show of the show, The Stem Cell Podcast and STEMCELL Technologies welcome Dr. Jack Parent. Dr. Parent is a professor of neurology, director of the Neurodevelopment and Regeneration Laboratory, and co-director of the Comprehensive Epilepsy Center in the University of Michigan Medical School.
His current research interests include neural stem cell transplantation to treat brain injury and neurodegeneration, and the modification of adult neural stem cells to promote brain repair after stroke or prevent epilepsy. Dr. Parent recently reported a novel way to create loss of function stem cell lines using gene editing and we speak with him more about this technique during our interview.
After the interview, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
Some Bacteria May Shield Tumor Cells Against a Common Chemotherapy Drug – According to this article, tumor cells grown with bacteria could stave off a common chemotherapy drug gemcitabine because some bacteria can inactivate it.
Change Your Diet, Change Your Microbiota – In this article, the microbiota of a group of hunter-gatherers in Tanzania undergo changes in composition depending on seasonal changes in their diets.
Mars Simulation Concludes – This article reports that six scientists emerged from eight months of earthly isolation atop Hawaii’s Mauna Loa volcano in a NASA-funded experiment intended to simulate the social isolation of a Mars mission and explore the resulting psychological effects.
North American Ash on Brink of Extinction – According to this article, populations of North America’s ash trees are in dramatic decline as a result of infections with invasive emerald ash borer beetles, with all but one the continent’s six species reclassified as critically endangered—one category away from extinction.
First Genetically Engineered Blood Stem Cell Clinical Trial Launched – This article reports that UCLA opens first engineered blood stem cell clinical trial for cancers with the NY-ESO-1 tumor marker.
Antibodies to Replace Genes For iPS Reprogramming – In this article, scientists from The Scripps Research Institute led by Kristin Baldwin have found a new approach to the “reprogramming” of ordinary adult cells into stem cells.
Stem Cell Talk – This article reveals that scientists from Markus Hengstschläger’s team at the Institute of Medical Genetics of MedUni Vienna have discovered the phenomenon of the “language of stem cells” where stem cells control the cells around them, inducing them to perform specific functions.
TAZ Protein Delivers Mixed Signals to Stem Cells – According to this article, a protein called TAZ can convey very different signals—depending upon not only which variety of stem cell, but also which part of the stem cell receives it.
iPSC To Gain More Insight into Lissencephaly – This article reports that by reprogramming skin cells into nerve cells, researchers at Karolinska Institutet in Sweden are creating cell models of the human brain.
Photo Reference: Courtesy of Dr. Jack Parent