Thanks again for tuning into THE Stem Cell Podcast, we are back with Episode 31. Be sure to go to stemcellpodcast.com and enter your name and email address to receive updates on the show and get entered for a free SCP T-shirt. We begin with our Science Round up, brought to you by Thermo Fisher. In the round up we blast through some of the hottest new publications including herpes to kill brain tumors, stomachs made from stem cells, stem cells made from using iPSC vs SCNT technology, breast milk stem cells, the origin of the penis, a mouse model of ebola, and many more. For the interview, we bring on a senior editor at Cell Stem Cell, Dr. Christina Lilliehook to share with us what goes on as an editor of a top tier science journal. In addition to a behind the scenes discussion, she also discusses how she got into a career in editing, and what it takes if you wanted to make that career choice. Then Yosif and I close the show by ranting about the use of Day 0 to describe the beginning of a protocol. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Arachnophobia Gets Cut Out Of Man’s Brain After Surgery To End His Seizures – This article discussed an instance where an unrelated seizure forced doctors to remove a portion of a man’s brain, inadvertently freeing him of his fear of spiders.
Mystery solved: Where the penis comes from – This article attempts to answer a question a lot of scientists ponder out loud that is key to much of life on Earth: Exactly how does the penis form?
Plasticity of the Aging Brain: New Directions in Cognitive Neuroscience – This article reviews the two new directions in the field of aging research with implications for plasticity.
Modeling Ebola in Mice – This article is about a study conducted by a team of scientists who have tested 47 genetically diverse mouse lines in response to their susceptibility to Ebola.
Gut Microbes and Jet Lag, Shift-Work Weight Gain – This article suggests that the body’s helpful bacteria may have internal clocks too that when disrupted will potentially boost the risk of obesity.
Dozens of Genes Associated with Autism in New Research – This article shows two new studies conducted by UC San Francisco scientists tying mutations in more than 100 genes to autism.
‘Treasure in saliva’ may reveal deadly diseases early enough to treat them, UCLA scientists report – This article reveals that simple saliva test is capable of diagnosing at an early stage diabetes, cancer, and perhaps neurological disorders and autoimmune diseases.
Violence genes may be responsible for one in 10 serious crimes – In this article, the scientists believed that they have discovered the genes responsible for high levels of rage violent behavior.
Jupiter-Sized Sunspot Largest for 24 Years – This article is about the solar eclipse that happened few weeks back, showing large sunspots responsible for creating some pretty stormy space weather.
New way to lose weight: Scientists stimulate brown fat to burn more energy from food – This article shows how scientists have now come closer to the goal of finding an efficient method for losing weight through the body’s own adenosine that activates brown fat and “browns” white fat.
Growth of CH3NH3PbI3 cuboids with controlled size for high-efficiency perovskite solar cells – This article reports that the growth of CH3NH3PbI3 cuboids with a controlled size via a two-step spin-coating procedure enables a power conversion efficiency of perovskite solar cells to exceed 16%.
Stem Cell Person of the Year 2014: Masayo Takahashi – This article announces Dr. Masayo Takahashi MD, PhD as the winner of the 2014 Stem Cell Person of the Year Award.
Stem cell patent to reach Supreme Court – This article states that the U.S. Supreme Court will be asked to intervene over a controversial embryonic stem cell patent according to the opponents of the patent.
Managers of discredited STAP stem cell study refund salary – This article announces that the top administrators of RIKEN, Japan’s national network of research laboratories will voluntarily return 1 to 3 months of their salaries to atone for their responsibility for the STAP stem cell fiasco.
Breast milk stem cells may be incorporated into baby – This article suggests that breast milk stem cells from mum could possibly go on to transform into parts of the baby’s body.
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids – This article describes a new and robust in vitro system for elucidating the mechanisms underlying human stomach development and disease.
Destroying brain tumors using herpes-loaded stem cells – This article reports that scientists from Harvard Stem Cell Institute may have a potential solution for how to more effectively kill tumor cells using cancer-killing viruses.
3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells – This article shows that single mouse ESCs directly embedded in Matrigel or defined synthetic matrices under neural induction conditions can clonally form neuroepithelial cysts containing a single lumen in 3D.
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease – This article describes how the scientists have applied induced pluripotent stem cell (iPSC) technology for Parkinson’s disease modeling using the monozygotic twins’ fibroblasts to evaluate and dissect the genetic and nongenetic contributions.
Comparable Frequencies of Coding Mutations and Loss of Imprinting in Human Pluripotent Cells Derived by Nuclear Transfer and Defined Factors – This article compares the genetic and epigenetic integrity of human nuclear-transfer embryonic stem cell (NT-ESC) lines and isogenic induced pluripotent stem cell (iPSC) lines, derived from the same somatic cell cultures of fetal, neonatal, and adult origin.
Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts – This article describes the potential of exploiting the synergism between miR-9/9∗-124 and transcription factors to generate specific neuronal subtypes or promote direct conversion of human fibroblasts into neurons.
We are working on a way to categorize all of the research papers we mention on the show and provide, and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available. You will also be entered to win a Stem Cell Podcast T-shirt, as we select one subscriber each month fro our mailing list.
Photo Reference: Courtesy of Dr. Christina Lilliehook