Welcome back for another great episode of the SCP. Be sure to visit www.StemCellPodcast.com and enter your email address in to receive all the show notes and links to all the papers we discuss. We start as always with the science round up brought to you by Thermo Fisher Scientific. In this episode, we discuss the latest and greatest papers ranging from a repurposed over active bladder medication, what stem cell companies to invest in for 2015, a review of the latest iPSC reprograming methods, a new optogenetics study relating to Parkinson’s disease, the sequencing of the oldest mammals genome, and stem cells from the eye to repair damaged corneas. We then talk to Dr. David Piper about disease model tools. Yosif and I then close the show ranting about Parafilm. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Booze Binge Has Immediate Effect On Immune System – According to this article, alcohol can wreak havoc on your immune system from the moment you start imbibing.
BPA Alternative Disrupts Normal Brain-Cell Growth, Is Tied To Hyperactivity, Study Says – In this article, researchers have shown why the chemical bisphenol-S (BPS) once thought to be a safe alternative to bisphenol-A, which was abandoned by manufacturers of baby bottles and sippy cups after a public outcry, might itself be more harmful than BPA.
World First: Scientists Observe DNA Shuttling Between Cells, Triggering Tumor Growth – This article describes how a team of scientists observed that DNA from a mouse’s second genome, or mitochondrial DNA, could be transferred from healthy tissue to tumor cells in mice, promoting cancer growth and spread.
Decline In Grants For Young Researchers Puts Future Of Science At Risk, Johns Hopkins President Writes – In this article, the president of John Hopkins University Ronald J. Daniels urges policy reforms and increased National Institutes of Health funding for young scientists who most of them are already leaving the academic biomedical workforce posing a grave risks for the future of science.
Teixobactin: Powerful New Antibiotic Kills Drug-Resistant Bacteria – In this article, a group of researchers led by Prof Kim Lewis of Northeastern University in Boston, Massachusetts, has discovered a new antibiotic Teixobactin that eliminates Methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium tuberculosis, Streptococcus pneumoniae, Bacillus anthracis and other dangerous pathogens without encountering any detectable resistance.
Weight Loss Drug Destroys Fat, Thanks To Bladder Medication: Finally A Treatment For Obesity? – This article describes how researchers figured out how FDA-approved drug mirabegron, typically used to treat overactive bladder, could boost brown fat’s metabolic burning efforts inside the body.
A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging – This article shows how scientists developed a protein scaffold, a repeating peptide array termed SunTag, which can recruit multiple copies of an antibody-fusion protein and may likely have many applications in imaging and controlling biological outputs.
Cold Virus Replicates Better At Cooler Temperatures – According to this article, researchers have found that the common cold virus can reproduce itself more efficiently in the cooler temperature found inside the nose than at core body temperature.
The Challenge Of Creating An HIV Vaccine: Virus Infects Very Cells Induced By Drug – This article tries to explain the reason why there is no vaccine for HIV/AIDS; it is because vaccines designed to protect against HIV backfire, leading to an increase, not decrease, in new infections which may be due to the higher number of activated CD4+ T cells.
“Imaginary Meal” Tricks The Body Into Losing Weight – In this article, Salk researchers have developed an entirely new type of pill called fexaramine that tricks the body into thinking it has consumed calories, causing it to burn fat.
Genome of Earth’s Longest-Lived Mammal Sequenced – This article shows that researchers have sequenced the genome of the Arctic giant, the circumpolar bowhead whale, and identified the key differences between these bi-centenarians and other mammals.
What Investors Are Looking At In The Stem Cell Sector – This article presents the different stem cell companies that have catalysts in the first quarter of 2015 in regards to stem cell stocks that could bring attention to the sector.
Cord Blood Registry and Cellular Dynamics International Announce Collaboration to Reprogram Newborn Stem Cells into Induced Pluripotent Stem Cells – In this article, Cord Blood Registry® (CBR®) and Cellular Dynamics International (NASDAQ: ICEL) (CDI) announced that they have entered into a research collaboration to reprogram newborn stem cells from both umbilical cord blood and umbilical cord tissue collected, processed and cryopreserved under CBR’s protocols into induced pluripotent stem cells (iPSCs) using CDI’s proprietary methods.
Gov. Cuomo Announces $36 Million to Accelerate Development of Stem Cell-Based Disease Cures – According to this article, Governor Andrew M. Cuomo announced that $36 million has been awarded to three research groups for the development of treatments for some of the most devastating conditions that could be helped with stem cell research.
Pitt Researcher Uses Stem Cells From The Eye To Repair Damaged Corneas – Based from this article, Dr. Sayan Basu, who has helped complete a research at the University of Pittsburgh School of Medicine, is using stem cells in a pilot project to restore the eyesight of patients with damaged corneas.
Steering Stem Cell Trafficking Into Pancreas Reverses Type 1 Diabetes – According to this article, researchers at Harvard-affiliated Brigham and Women’s Hospital (BWH) studying mesenchymal stem cells (MSCs) — a cell type useful in treating immune-related diseases — have uncovered a way to enhance and prolong the cells’ therapeutic effects in a preclinical model of type 1 diabetes.
Genetic and Functional Diversity of Propagating Cells in Glioblastoma – This article is about Glioblastoma (GBM), a lethal malignancy whose clinical intransigence has been linked to extensive intraclonal genetic and phenotypic diversity and the common emergence of therapeutic resistance.
Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors – This article shows that direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors.
Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration – In this article, researchers have shown that activation of cytokine-STAT5 increased intestinal epithelial stem cells (IESC) proliferation, accelerated crypt regeneration, and conferred resistance to intestinal injury.
A Comparison Of Non-Integrating Reprogramming Methods – This article discusses the different advantages and shortcomings of each reprogramming methods, and present and review the results of a survey of a large number of human reprogramming laboratories on their independent experiences and preferences.
Optogenetics Enables Functional Analysis Of Human Embryonic Stem Cell–Derived Grafts In A Parkinson’s Disease Model – This article describes how the researchers use optogenetics to modulate in real time electrophysiological and neurochemical properties of mesencephalic dopaminergic (mesDA) neurons derived from human embryonic stem cells (hESCs).
Photo Reference: Courtesy of Dr. David Piper