Welcome to another episode of THE Stem Cell Podcast. Thanks everyone for the continued support and be sure to visit stemcellpodcast.com to sign up for our e-newsletter and see all the great resources we have there for everyone. What a great show we have this week featuring awesome new stem cell news and a great interview with a real stem cell “big fish.” We start as always with our science round up sponsored by Thermo-Fisher where we discuss some of the most recent science/stem cell news. Some of the topics discussed on this episode range from approval of a 3 parent gene therapy, stem cells for breast implants, stem cell derived brain cells to repair radiation damage, a rapid HIV test on your iPhone, a detailed bacteria map of NYC, info about tattoos on the ancient iceman, and optogenetics and neurons. Then we bring on world renowned stem cell researcher Dr. Lorenz Studer to talk about his work, latest paper, and progress towards a new therapy for Parkinson’s Disease. Then all three of us rant about Facebook invites to play games. Enjoy!
More About Our Guest Dr. Lorenz Studer
Dr. Lorenz Studer is the founding director of the Sloan-Kettering Center for Stem Cell Biology a Member in the Developmental Biology Program and the Department of Neurosurgery and Professor in Neuroscience at Weill-Cornell Graduate School.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Novel “Smart” Insulin Automatically Adjusts Blood Sugar in Diabetic Mouse Model – In this article, scientists have created Ins-PBA-F, a long-lasting “smart” insulin that self-activates when blood sugar soars, eliminating the need for additional boosts of insulin, and reducing the dangers that come with inaccurate dosing.
Scientists Find Mysterious Magnetism in Earth’s Inner Core – According to this article, a team of U.S. and Chinese geophysicists suggests that the innermost core is rotated on its side compared to its outer layer and the team also provides new clues about how the inner core formed and began to solidify.
Test For HIV In Just 15 Minutes With This $34 Smartphone Dongle – In this article, a dongle created by Columbia University researchers can turn any smartphone (whether iPhones or Android devices) into an HIV and syphilis tester.
Research Team Identifies Link Between Inflammation And Type 2 Diabetes – This article describes how a Yale-led research team has identified the molecular mechanism by which insulin normally inhibits production of glucose by the liver and why this process stops working in patients with type 2 diabetes, leading to hyperglycemia.
Mutations Linked to Repair of Chromosome Ends May Make Emphysema More Likely in Smokers – This article reveals that mutations in telomerase reverse transcriptase (TERT) gene that helps repair damaged chromosome ends may make smokers, especially female smokers more susceptible to emphysema.
Researchers Produce First Map of New York City Subway System Microbes – This article identifies the microbes present in the New York City subway system through a pathogen map or PathoMap and could be used for long-term, accurate disease surveillance, bioterrorism threat mitigation, and large scale health management for New York.
Researchers Discover Insulin-Decreasing Hormone In Flies, Humans – According to this article, a hormone called limostatin that decreases insulin production during starvation has been identified in fruit flies and humans.
A Neural Biomarker of Psychological Vulnerability to Future Life Stress – This article highlights a readily assayed biomarker, threat-related amygdala reactivity, which predicts psychological vulnerability to commonly experienced stressors and represents a discrete target for intervention and prevention.
New Tattoos Found on Öetzi the Iceman – In this article, new scans have revealed a total of 61 tattoos on the 5,300-year-old mummified body of Ötzi the Iceman, reigniting the debate on whether the inkings were a form of acupuncture that predates the first recorded use of the practice in China by 2,000 years.
Real-Time Deformability Cytometry: On-The-Fly Cell Mechanical Phenotyping – In this article, researchers introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical characterization of large populations (>100,000 cells) with analysis rates greater than 100 cells/s.
Scientists Discover ‘Reset’ Button For Brain’s Biological Clock – According to this article, researchers at Vanderbilt University have discovered a “reset” button for the circadian or biological clock, which could pave the way for more effective treatments for seasonal affective disorder (SAD), jet lag and some of the negative health effects of shift work.
Green Tea Ingredient May Target Protein To Kill Oral Cancer Cells – In this article, Penn State food scientists have found that the compound epigallocatechin-3-gallate (EGCG) found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone.
U.K. Parliament Approves Controversial Three-Parent Mitochondrial Gene Therapy – This article announces that the United Kingdom’s House of Commons voted overwhelmingly today to allow British researchers to pursue a new fertility treatment using a technique called mitochondrial DNA replacement therapy that could prevent certain kinds of genetic diseases.
Cell Therapy Raises Record-Breaking Crowdfunding For Stem Cell Drug – According to this article, UK biotech company Cell Therapy has raised over £691,000 ($1 million) through crowdfunding on Crowdcube.
Robert Rey, ‘Dr. 90210,’ Turns To Breast Augmentation With Stem Cells For Hollywood Stars –In this article, Dr. Robert Rey, better known as Dr. 90210, told TMZ yesterday about the new rage in breast augmentation, and it can make people thinner, too.
Did Stem Cells Save Gordie Howe? – This article talks about how Gordie Howie – a.k.a. Mr. Hockey, after having stroke received treatments with neural stem cells injected into the spinal canal and mesenchymal stem cells by intravenous infusion that has reportedly improved his health.
Stem Cells Cure Hope For Diabetes – According to this article, a group of researchers talk about the possibilities of finding a cure for type 1 diabetes involving trials using stem cells take from the bone marrow and using them to stimulate insulin production.
Panel Passes Abortion, Stem Cell Research Ban Bills – This article announces that a bill to further restrict abortion in Oklahoma and another to make embryonic stem cell research illegal both cleared a House committee on Wednesday, despite concerns from a doctor on the panel.
Can Stem Cells Be Taught to Repair a Radiation-Damaged Brain? – In this article, researchers turned stem cells into young central nervous system cells that can mature into oligodendrocytes, which support nerve cells, repairing some of the radiation injury brought about during cancer treatments.
Cellular Dynamics Manufactures cGMP HLA “Superdonor” Stem Cell Lines to Enable Cell Therapy With Genetic Matching – This article announces that Cellular Dynamics has manufactured two human leukocyte antigens (HLA) “superdonors” which will provide a beneficial genetic match to large number of patients.
Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans – This article examines the role of the lung extracellular matrix or ECM in differentiation of pluripotent cells in vitro and demonstrates the robust inductive capacity of the native lung matrix alone.
P63+Krt5+ Distal Airway Stem Cells Are Essential For Lung Regeneration – This article demonstrates lung regeneration in mice following H1N1 influenza virus infection, and linked distal airway stem cells expressing Trp63 (p63) and keratin 5, called DASCp63/Krt5, to the process of pulmonary function recovery.
Optogenetics Enables Functional Analysis Of Human Embryonic Stem Cell–Derived Grafts In A Parkinson’s Disease Model – This article describes the use of optogenetics to modulate in real time electrophysiological and neurochemical properties of mesencephalic dopaminergic (mesDA) neurons derived from human embryonic stem cells (hESCs).
Photo Reference: Courtesy of Dr. Studer