Welcome everybody to Episode 42, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from, genomic analyses of brain tumors, cheap long lasting cell phone batteries, expansion microscopy, feeder stem cell culture may be better than feeder free, hESCs are not being used as gold standard as much anymore, stem cells for dogs, a new RIKEN president, a new possible model for liver disease using iPSCs, etc. Then we bring on neuroscientist and stem cell pioneer Dr. Fred “Rusty” Gage, a professor at the Salk Institute where he discusses past, present, and future work of stem cells and neurogenesis. We then finish off the show with a rant on packing peanuts.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Too Much Of A Bad Thing Can Be Good In Brain Tumors – This article revealed that DNA mutations can cause cancer but in some cases, more mutations may mean a better prognosis for patients like the one subtype of the most malignant brain tumor, called glioblastoma, or GBM.
Turbo-Charging Hormone May Help Regrow The Heart, Animal Study Shows – In this article, researchers at the Victor Chang Cardiac Research Institute discovered how to stimulate muscle regrowth in the heart of a mouse, which could be particularly important in looking at new treatments for those who suffer future heart attacks.
Aluminum Battery From Stanford Offers Safe Alternative To Conventional Batteries – According to this article, Stanford University scientists have invented the first high-performance aluminum battery that’s fast-charging, long-lasting and inexpensive that could replace many of the lithium-ion and alkaline batteries in wide use today.
Blackpoll Warblers Migrate Thousands of Miles across Atlantic Ocean, Scientists Find – In this article, a team of ornithologists led by William DeLuca of the University of Massachusetts, Amherst, reports the first direct evidence that the blackpoll warbler (Setophaga striata), relatively small songbirds, completes an autumn trans-Atlantic migration ranging from 2,270 to 2,770 km (1,410 to 1,721 miles) and requiring 2 to 3 days of non-stop flight.
Africa: Biodiversity Damage Mapped By Global Land-Use Study – According to this article, study concluded that, if human impacts continue to grow as they have been, future losses in biodiversity will be concentrated in biodiverse but economically poor countries.
Blown-Up Brains Reveal Nanoscale Details – In this article, a study showed that material used in diaper absorbant can make brain tissue bigger and enable ordinary microscopes to resolve features down to 60 nanometers; this technique is called expansion microscopy.
Repurposed Experimental Cancer Drug Restores Brain Function In Mouse Models Of Alzheimer’s Disease – In this article, scientists have found that saracatinib, a compound originally developed as a cancer therapy potentially could be used to treat Alzheimer’s disease.
Stemming Genetic Changes in Cultured Cells – According to this article, researchers have found that the fewest genetic changes arise in embryonic stem cells (ESCs) that are grown on a substrate layer of “feeder cells”—non-dividing cells that provide nutrients and help ESCs attach to their culture dishes—and passaged mechanically, that is, broken into clumps before being moved into new vessels.
Study: Saccharin Shows Promise As Cancer Inhibitor – This article shows that the artificial sweetener saccharin shows considerable promise for its ability to inhibit an enzyme upregulated in many cancers, helping tumor cells survive and metastasize.
Researchers May Have Solved Origin-Of-Life Conundrum – In this article, chemists report that a pair of simple compounds called acetylene and formaldehyde, which would have been abundant on early Earth, can give rise to a network of simple reactions that produce the three major classes of biomolecules—nucleic acids, amino acids, and lipids—needed for the earliest form of life to get its start.
Malaria Parasite Attracts Mosquitoes with Perfume – This article reveals that Plasmodium—the malaria parasite manufactures alluring odor molecules, called terpenes using a chloroplast-like organelle that attract mosquitoes.
Why Is The Scientific World Abuzz About An Unpublished Paper? Because It Could Permanently Change Human DNA – In this article, scientists around the world are anticipating the results of a Chinese study that would mark the first time DNA in a human embryo has been modified in a way that would carry into future generations.
Meat Grown In A Laboratory Soon To Become Commercially Viable, Says Scientist – This article announces that meat grown in a laboratory will become commercially viable in the next decade according to the scientist who grew the world’s first stem cell burger.
New RIKEN Chief Pledges To Restore Public Faith In Japanese Lab System – In this article, Hiroshi Matsumoto, the new president of RIKEN – Japan’s network of labs, pledged to follow through on his predecessor’s plans for addressing shortcomings that created an environment for research misconduct.
Stem Cell Therapy For Dogs Draws Support, Detractors – This article describes the stem cell treatment for dogs with hip dysplasia or arthritis.
Human Embryonic and Induced Pluripotent Stem Cell Research Trends: Complementation and Diversification of the Field – According to this article, research in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are increasingly being used in more independent research and application areas with the former still being used as a “gold standard,” but in a declining proportion of publications.
Cell-Published Research Reveals Plucking May Treat Hair Loss – According to this article, a new research reveals that plucking (that requires technique) will initiate “signals” to follicles to grow hair.
Stem Cells Lurking In Tumors Can Resist Treatment – In this article, a mouse study at Washington University School of Medicine in St. Louis, Missouri, shows that slow-growing tumors also have treatment-resistant stem cells prompting worries among medical experts.
Early Reprogramming Regulators Identified By Prospective Isolation And Mass Cytometry – According to this article, single-cell mass cytometry and prospective isolation show that distinct intermediates are transient and bridge the gap between donor cell silencing and pluripotency marker acquisition during the early, presumably stochastic, reprogramming phase.
Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells – In this article, scientists develop a bioinformatic approach to detect differences between the genomic programs of induced pluripotent stem cells (iPSCs) derived from diseased versus normal human cohorts as they emerge during in vitro directed differentiation.
Photo Reference: Courtesy of Dr. Gage