The Stem Cell Podcast is proud to bring you our 50th Episode. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode, we discuss topics ranging from the US going to Pluto, a fast growing black hole, discovery of taste of fat, planned parenthood selling fetal tissue, stem cell stocks, functional liver cells from stem cells and more. For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on internationally recognized stem cell pioneer Dr. George Daley from Children’s Hospital Boston and the Harvard Stem Cell Institute to discuss all things stem cells. We then finish off the show with a rant on wobbly tables. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
New Ebola Vaccine Has ‘100 Percent’ Effectiveness In Early Results – In this article, researchers have announced promising results of a new vaccine’s trial called Ebola ça Suffit — French for “Ebola that’s enough” funded by World Health Organization, in Guinea, one of several countries affected by a historic outbreak in West Africa.
Synthetic Ribosome Can Keep Bacteria Alive – According to this article, scientists have engineered a tethered ribosome that works nearly as well as the real thing—an organelle that produces all the proteins and enzymes within the cell.
Anxiety And Depression Caused By Stress Linked To Gut Bacteria Living In Intestines, Scientists Find – This article reports that anxious and depressive behavior brought on by exposure to stress in early life appears only to be triggered if microbes are present in the gut.
Scientists Have Discovered The Taste Of Fat And Say It Could Hold The Key To Tackling Obesity – In this article, scientists describe the taste of fat as a unique and unpleasant taste called oleogustus, and suggest that its identification could lead to new ways of fighting obesity and heart disease, and to the creation of improved fat replacements.
Study Shows Glitazone Antidiabetic Drug May Reduce Risk Of Parkinson’s Disease – According to this article, researchers found that diabetes patients taking glitazone antidiabetes drugs (either rosiglitazone or pioglitazone) had a 28% lower incidence of Parkinson’s disease than people taking other treatments for diabetes who had never taken glitazones.
Long-term Memories Are Maintained by Prion-like Proteins – In this article, research from Eric Kandel’s lab at Columbia University Medical Center (CUMC) reveals that different prions are critical for the long-term storage of memories.
Astronomers Spot Black Hole So big, It Defies Current Theories Of Galaxy Evolution – This article describes the discovery of a galaxy called CID-947 with a black hole that makes up 10% of its mass has left scientists dumbfounded, possibly overturning current theories of how galaxies evolve.
Physicists Confirm Existence of Rare Pentaquarks – According to this article, Professors Sheldon Stone and Tomasz Skwarnicki, doctoral student Nathan Jurik and former University research associate Liming Zhang are on the team that has confirmed the existence of two rare pentaquark states.
Should Aborted Foetuses Be Used For Stem Cell Research? –This article reports the recent incident where US company Planned Parenthood was found to be offering foetal tissue to buyers without the parents’ knowledge has raised serious ethical questions around the use of foetuses in stem cell research.
Four Stem-Cell Stocks With Promise – In this article, Reni Benjamin, a biotech analyst at Raymond James Financial shared four stem cell stocks that has upside potential in the second half of the year.
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial – In this article, scientists share lessons while taking a discovery made using iPSCs into a clinical trial.
Scientists Create Functional Liver Cells From Stem Cells – According to this article, scientists from the Hebrew University of Jerusalem’s Alexander Grass Center for Bioengineering report that they produced large amounts of functional liver cells from human embryonic and genetic engineered stem cells.
Researchers Create Model Of Early Human Heart Development From Stem Cells – This article reports that UC Berkeley researchers, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and as a drug-screening tool to make pregnancies safer.
Stem Cells Could Treat Mitochondrial Disease – In this article, researchers generated human stem cells in the lab, repaired common mitochondrial defects, and reported they were able to rescue cell function.
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury – This article unveils general principles underlying Neural Stem Cell activation and lineage priming and opens potential avenues for regenerative medicine in the brain.
Generation Of Vascular Endothelial And Smooth Muscle Cells From Human Pluripotent Stem Cells – In this article, researchers report the rapid and efficient differentiation of human pluripotent stem cells into vascular endothelial and smooth muscle cells.
Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9 – According to this article, CRISPR-Cas9 and targeted sgRNAs can revert large inversions in hemophilia A iPSCs.
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells – In this article, researchers show that human induced pluripotent stem cells (hiPSCs) differentiate into incipient mesoderm-like cells (iMeLCs), which robustly generate human primordial germ cell-like cells (hPGCLCs) that can be purified using the surface markers EpCAM and INTEGRINα6.
Photo Reference: Courtesy of Dr. George Daley of the Harvard Stem Cell Institute