Alright everyone, we are back with an exciting show with a timely topic: Zika Virus. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
We start off as always with the Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including:
- Zika virus is more dangerous then we thought
- Plants use prions to remember
- Dragons sleep like us
- EPA boosts estimate of US methane emission
- Mini beating hearts grown using stem cells
- Chemical control of grafted neurons in a mouse model of Parkinson’s
- A new way to target cancer stem cells
- A new way to grow blood stem cells
The Interview with Dr. Arnold Kriegstein discussing the Zika Virus
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on stem cell researcher Dr. Arnold Kriegstein from UCSF to discuss his work and latest paper in Cell Stem Cell on how the Zika virus affects neural stem cells. After this we rant about people who only think about themselves.
Below are all of the papers mentioned in this episode of The Stem Cell Podcast. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Zika Is MORE Dangerous Than We Thought – This article describes the danger of Zika virus like microcephaly in children born from women who have had Zika during pregnancy and Guillain-Barre syndrome – a nerve disorder that causes temporary muscle paralysis.
Plants Use Prions To Remember – This article reveals that prions – proteins that change shape and shift tasks, may occur in plants as a form of memory.
Uncertainty Is Stressful, But That Stress May Not Always Be Bad – This article demonstrates that subjective estimates of uncertainty predict the dynamics of subjective and physiological stress responses.
Dragons Sleep Like Us – According to this article, sleeping lizards appear to share distinctive brain activity patterns with sleeping birds and mammals.
EPA Boosts Estimate of U.S. Methane Emissions – This article reports that US. Environmental Protection Agency has boosted its estimate of total U.S. methane emissions by 13 percent which is an increase of more than 3.4 million metric tons of the greenhouse gas and has the same long-term global warming impact as a year’s worth of emissions from about 20 million cars.
Risky Skull Surgery Done for Ritual Reasons 6,000 Years Ago – This article reveals that between 6,000 and 4,000 years ago, skilled surgeons in southwestern Russia cut holes the size of silver dollars or larger out of the backs of people’s skills for ritual reasons.
Miniature, Beating Hearts Grown Using Stem Cells – In this article, researchers describe an approach that combines features of Engineered Heart Muscle (EHM) and cardiospheres: Micro-Heart Muscle (μHM) arrays, in which elongated muscle fibers are formed in an easily fabricated template, with as few as 2,000 iPS-CM per individual tissue.
Genome Editing of Lineage Determinants In Human Pluripotent Stem Cells Reveals Mechanisms Of Pancreatic Development And Diabetes – In this article, researchers not only verified conserved gene requirements between mice and humans but also revealed a number of previously unsuspected developmental mechanisms with implications for type 2 diabetes.
Chemical Control Of Grafted Human PSC-Derived Neurons In A Mouse Model Of Parkinson’s Disease – This article shows tunable rescue of motor function in a mouse model of PD, following transplantation of human midbrain dopaminergic (mDA) neurons differentiated from hPSCs engineered to express DREADDs (designer receptors exclusively activated by designer drug).
Combined Inhibition of DNMT and HDAC Blocks The Tumorigenicity of Cancer Stem-Like Cells And Attenuates Mammary Tumor Growth – According to this article, a combination of the DNMT inhibitor 5-azacytidine and the HDAC inhibitor butyrate markedly reduced CSC abundance and increased the overall survival in this mouse model.
Scientists Uncover New Way to Grow Rare Life-Saving Blood Stem Cells – This article shows that overexpression of the RNA-binding protein Musashi-2 (MSI2) induces multiple pro-self-renewal phenotypes, including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion of long-term repopulating HSCs.
Photo Reference: Courtesy of Dr. Arnold Kriegstein