Welcome everyone to Episode 72 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including:
- Young sunflowers use circadian rhythms to follow the sun.
- Young people agree to pay for antiaging trials.
- Science literacy does not necessarily lead to greater support of science.
- Chimera research requires extra review according to NIH policy.
- Correction of WAS-iPSCs restores lymphoid cell development and function.
- Mammalian chimeras are a provocative resource for regenerative medicine.
The interview with Dr. Ritchie Ho
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on Dr. Ritchie Ho, a postdoctoral fellow from Cedars-Sinai with his latest study on induced pluripotent stem cell in-vitro model of ALS. After that we close the show with our signature rant on “unboxing videos.” Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned in This Session Include:
Circadian Clock Influences Young Sunflowers to Follow the Sun – According to this article, a new research from University of California Davis shows how sunflowers use their circadian clock to anticipate the dawn and follow the sun across the sky during the day.
Humans Prefer the Gait of Mutant Horses – In this article, researchers examine historic horse remains for the DMRT3 SNP, tracking the origin of gaitedness to Medieval England between 850 and 900 AD.
Young Blood Antiaging Trial Raises Questions – This article reports that a startup company Ambrosia has now launched the first pay-to-participate clinical trial in the United States to test the antiaging benefits of young blood in relatively healthy people.
Science Literacy Isn’t Just About What People Know, It’s Also About Their Communities – According to this article, increasing science literacy will not lead to appreciably greater support for science but may be shaped by factors such as values and beliefs.
NIH Proposes Removal of Moratorium On Chimera Research – This article reports that a proposed National Institutes of Health (NIH) policy would require extra review for certain studies that create chimeras, or animals with both human and animal cells.
Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects – In this article, induced pluripotent stem cells (iPSCs) were derived from a Wiskott-Aldrich Syndrome patient (WAS-iPSC) and the endogenous chromosomal WAS locus was targeted with a wtWAS-2A-eGFP transgene using zinc finger nucleases (ZFNs) to generate corrected WAS-iPSC (cWAS-iPSC).
Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research – This article highlights the applications and current limitations presented by intra- and inter-species chimeras and their future contribution to the stem cell field.
Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells – In this article, researchers report a three-step protocol to differentiate human pluripotent stem cells (hPSCs) into Gonadotropin-releasing hormone (GnRH)-secreting neurons which regulate puberty and reproduction.
Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells – According to this article, researchers identified a set of genetic factors that could robustly induce human pluripotent stem cells (hPSCs) into GABAergic neurons (iGNs) with high efficiency.
Photo Reference: Courtesy of Dr. Ritchie Ho