Welcome everyone to Episode 75 of The Stem Cell Podcast, in today’s episode we discuss stem cells and culture conditions with Dr. Joshua Brickman. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
We begin with the world famous Science Round Up and discuss the latest science/stem cell news including:
- Watching bugs gain antibiotic resistance.
- Lyme bacteria swing on blood vessels.
- No T-Cell Response to iPSC derived RPE.
- Stem cells to grow 3D lung in a dish.
- Parkinson’s iPSC Derived Neurons Exhibit Disease in a Dish.
- Motherless babies possible?
The interview with Dr. Joshua Brickman
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on stem cell biologist Dr. Joshua Brickman from The University of Copenhagen to discuss his work on stem cells and culture conditions. After this we close the show with a signature SCP rant. Enjoy!
Below are all of the research papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned in This Session Include:
Scientists Watch as Bacteria Evolve Antibiotic Resistance – In this article, a petri dish more than a meter long helped scientists visualize the evolution of antibiotic resistance in E. coli bacteria.
Lyme Bacteria Swap ‘Catch Bonds’ to Navigate Blood Vessels – According to this article, the corkscrew-shaped bacteria that cause Lyme disease (Borrelia burgdorferi) attach themselves to the sides of blood vessels using special bonds that get stronger under stress.
Maybe You Don’t Need to Burp Your Baby – This article reports that there’s scant scientific evidence that burping after meals actually does anything helpful for babies.
Pigeons Can Read a Little Bit – In this article, pigeons moved from learning to eat from a food hopper, to recognizing shapes, to learning words through gradual training,
Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors – In this article, researchers established human retinal pigment epithelial (RPE) cells from induced pluripotent stem cells (iPSCs) in HLA homozygote donors.
Scientists Use Stem Cells to Grow 3D Lung-In-A-Dish – According to this article, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have succeeded in creating three-dimensional lung “organoids” by coating tiny gel beads with lung-derived stem cells and then allowing them to self-assemble into the shapes of the air sacs found in human lungs.
Motherless Babies Possible as Scientists Create Live Offspring Without Need for Female Egg – This article shows that embryos could be created from cells which carry all their chromosomes leading to the theory that any cell in the human body could be fertilised by a sperm.
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation – In this article, researchers demonstrate that the identification of disease-related phenotypes in Parkinson’s disease (PD) – patient-specific induced pluripotent stem cell (iPSC)-derived midbrain dopamine (mDA) neurons depends on the type of differentiation protocol utilized.
Photo Reference: Courtesy of Dr. Joshua Brickman