Welcome everyone to Episode 80 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
We begin with the world famous Science Round Up and discuss the latest science/stem cell news including:
- Dogs form memories of experiences.
- Lower social status affects immune system.
- A new fetal genome test.
- Synthetic recording and in situ readout of lineage information.
- Take a journey to the inside of a stem cell.
- Neural progenitors on the outside of brain.
- Inhibition of mTOR pauses pluripotency.
The interview with Dr. Jen Adair
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on Dr. Jen Adair, assistant member of the clinical research division at the Fred Hutch Cancer Research Center, and Assistant Professor of medical oncology at the University of Washington School of Medicine. Adair’s group investigates retrovirus-based gene transfer into hematopoietic stem cells as a viable treatment for genetic, malignant and infectious diseases. After this we close the show with a signature SCP rant. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned in This Session Include:
Dogs Form Memories of Experiences – This article suggests that dogs possess some version of episodic memory, which allows them to recall personal experiences, and not just simple associations between, for instance, sitting and getting a treat.
Lower Social Status Can Alter the Immune System – According to this article, a new study manipulating the pecking order of monkeys finds that low social status kicks the immune system into high gear, leading to unwanted inflammation akin to that in people with chronic diseases.
A New Fetal Genome Test – This article reports that by doing a Pap smear as early as five weeks into a pregnancy, researchers can collect enough fetal cells to test for abnormalities linked to more than 6,000 genetic disorders.
Old Blood Carries Risks for Brain – This article reveals that after transfusions of young blood, old mice still had lower numbers of newborn nerve cells in the hippocampus, a brain structure important for learning and memory.
Synthetic Recording and In Situ Readout of Lineage Information in Single Cells – In this article, researchers have developed a new method for reading the history and “family trees” of cells called MEMOIR (Memory by Engineered Mutagenesis with Optical In situ Readout) which can record the life history of animal cells, their relationships with other cells, communication patterns, and the influential events that have shaped them.
Take A Journey Into The Center Of A Stem Cell – In this article, scientists have journeyed to the center of a stem cell that’s maturing into a nerve cell using a powerful X-ray microscope to snap pictures of stem cells at different stages of differentiation.
Neural Progenitors Found in Outer Brain Covering – According to this article, a cross-domain study directed by professor Peter Carmeliet (VIB – KU Leuven) reveals that there are neural progenitors called meninges in the protective membranes that enclose the brain.
Inhibition of mTOR Induces a Paused Pluripotent State – This article reports that the partial inhibition of mechanistic target of rapamycin (mTOR), a major nutrient sensor and promoter of growth, induces reversible pausing of mouse blastocyst development and allows their prolonged culture ex vivo.
Photo Reference: Courtesy of Dr. Jen Adair