Welcome everyone to Episode 87 of The Stem Cell Podcast. On this episode we speak with Dr. Justin Lathia on the topic of “Cancer Stem Cell Evasion”.
The Science Round Up
For this week’s Science Round Up, we’d like to introduce one of Connexon’s most popular newsletters, Cancer Stem Cell News. As with all of Connexon’s 20 science newsletters, Cancer Stem Cell News keeps readers current on the latest findings and technologies in their field while saving time. They let you get more research done because you spend less time digging through the literature for the good stuff! Subscribe at cancerstemcellnews.com and check out their other newsletters while you’re there.
This week, in the world-famous Science Round Up we discuss the latest science/stem cell news including:
- Birth defects in the US on the rise from Zika.
- New strategy for sterilizing mosquitoes.
- New imaging technique for DNA.
- Two types of stem cells to grow mouse embryo.
- Stem cell science in space.
- Stem cells in breasts may be linked to breast cancer.
- Obesity can reprogram muscle stem cells.
The interview with Dr. Justin Lathia
The interview portion of this episode is sponsored by STEMCELL Technologies, who is offering a free sample for a NeuroCult NS-A for Brain Tumor Stem Cells. It’s the most referenced specialized culture medium for brain tumor stem cell culture which:
- Supports the isolation and proliferation of brain tumor stem cells from both pediatric and adult tumors, and from a variety of CNS tumor types
- Gives you an advantage because it’s:
- Specialized – maintain humans neural/brain tumor stem cells in long-term culture
- Versatile – supports a variety of tumor types, using either neurosphere or monolayer culture techniques
- Consistent – Conforms to stringent quality control standards
The Stem Cell Podcast listeners can request a free sample at www.stemcell.com/SampleNeuroCult
For this episode’s interview, we bring on Dr. Justin Lathia, Assistant Professor in the Department of Cellular and Molecular Medicine at the Lerner Research Institute, Cleveland Clinic. Dr. Lathia’s research focus is on how stem cell programs drive tumor progression and therapeutic resistance. To achieve this goal, he has had active projects in cell adhesion mechanisms, cell-cell communication, and the interaction between tumor cells and the immune system. Most recently Dr. Lathia’s group published a paper in Cell Stem Cell describing a novel method on how stem cells in brain tumors evade immune signals around them. After this we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
Certain Birth Defects Are on the Rise Since Zika Arrived in the U.S. – According to this article, certain birth defects were 20 times more prevalent in babies born to Zika virus–infected mothers in the U.S. in 2016 than they were before the virus cropped up in the United States, a CDC study suggests.
Bacteria Genes Offer New Strategy for Sterilizing Mosquitoes – In this article, a pair of bacterial genes called cifA and cifB, connected to the sterility mechanism of Wolbachia may enable genetic engineering strategies for curbing populations of virus-transmitting mosquitoes.
New Imaging Technique Catches DNA ‘Flickering’ On – This article describes a new imaging technique that takes advantage of DNA’s natural ability to “blink” in response to stimulating light.
Gastric Bypass Controls Diabetes Long Term Better Than Other Methods – This article reveals that people who undergo gastric bypass surgery are more likely to experience a remission of their diabetes than patients who receive a gastric sleeve or intensive management of diet and exercise, according to a new study.
Scientists Use Two Types Of Stem Cells To Grow Artificial Mouse “Embryo” – In this article, scientists combine mouse embryonic stem cells (ESCs) and extra-embryonic trophoblast stem cells (TSCs) in a 3D-scaffold to generate structures whose morphogenesis is remarkably similar to natural embryos.
Stem Cell Science in Space Happening with SpaceX Rocket – This article reports that the SpaceX rocket carrying samples of donated adult stem cells from a research laboratory at Mayo Clinic’s Florida campus launched from NASA’s Kennedy Space Center in Cape Canaveral, Fla., on Feb. 19.
Australian Researchers Have Discovered Stem Cells in The Breast That May Be Linked to A High-Risk Form of Breast Cancer – In this article, located in a region near the nipple, the newly-found stem cells have many molecular similarities to a subtype of ‘triple negative’ breast cancers known as claudin-low cancers.
Obesity Can Reprogram Muscle Stem Cells – According to this article, by comparing the DNA methylation in immature and mature muscle cells from healthy individuals, Cajsa Davegårdh discovered that the actual degree of methylation had a major impact on the maturation process.
Photo Reference: Courtesy of Dr. Justin Lathia