Welcome everyone to Episode 92 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter.
The Science Round Up
For this week’s round-up, we’d like to remind listeners of one of Connexon’s original newsletters, Mesenchymal Cell News. Covering both in vivo and in vitro research, Mesenchymal Cell News keeps subscribers current with the latest publications, industry & policy news, as well as jobs and events related to MSC research. Join more than 4,000 subscribers and almost 3,000 Twitter followers for free at www.mesenchymalcellnews.com.
This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- Toddlers and TV linked to speech delay.
- Breast cancer cells spread in groups.
- An exercise pill??
- Immune cells regulate heartbeat.
- Bone marrow stem cells for ALS?
- Large bank of human stem cell lines made in Europe.
- Vitamin deficiency bad for stem cells.
- Single cell RNA-Seq and human germ line cells.
The interview with Dr. Farshid Guilak
The interview portion of this episode is brought to you by STEMCELL Technologies product line called MesenCult™ for mesenchymal stem and progenitor cell research
Here are the highlights:
- A variety of MesenCult™ media and reagents are specifically developed and optimized to derive, expand and differentiate MSCs.
- This includes defined, animal component-free media formulations for culturing MSCs to minimize experimental variability and immunogenic concerns.
- To learn more, please visit stemcell.com/MSCworkflow
For this episode’s interview, we bring on Dr. Farshid Guilak. Dr Guilak is a Professor in the Department of Orthopaedic Surgery at Washington University and Director of Research for the Shriners Hospitals for Children – St. Louis Shriners. His laboratory is pursuing a multidisciplinary approach to investigate the etiology and pathogenesis of osteoarthritis, as a basis for the development of new pharmacologic and stem-cell therapies. Osteoarthritis is a painful and debilitating disease of the synovial joints that affects over 27 million people in the United States. After this fascinating conversation we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
Toddlers’ Screen Time Linked to Speech Delays and Lost Sleep, But… – According to this article, the use of tablets and other handheld digital devices are associated with speech delays and less night sleep in young children, links that scientists, doctors and parents are all eager to explore.
Breast Cancer Cells Spread in Groups – In this article, a study says breast cancer cells may break away from the main tumor in clumps, already bearing most of the mutations that will drive cancer recurrence.
An Exercise Pill??? – This article reports that an experimental drug touted as “exercise in a pill” has dramatically increased endurance in couch potato mice, even after a lifetime of inactivity by adjusting the body’s metabolism, allowing muscles to favor burning fat over sugar.
Immune Cells May Help Regulate Our Heart Beat – According to this article, immune system cells called macrophages, which usually protect the body from invading pathogens, also help electricity flow between muscle cells to keep the heart pumping.
Bone Marrow Stem Cells for ALS – In this article, researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease amyotrophic lateral sclerosis (ALS) by repairing damage to the blood-spinal cord barrier.
Large Bank of Human Stem Cell Lines Made in Europe – This article reports that the 711 induced pluripotent stem cell (iPSC) lines derived from 301 healthy volunteers were released by a large European consortium – the Human Induced Pluripotent Stem Cells Initiative (HipSci) – in the journal Nature.
Vitamin Deficiency Not Good for Blood Stem Cells – According to this article, lack of vitamin A in the body has a detrimental effect on the hematopoietic system in the bone marrow.
Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions – In this article, researchers performed single-cell RNA-seq analysis of over 2,000 human fetal germ cells (FGCs) and their gonadal niche cells in female and male human embryos spanning several developmental stages.
Photo Reference: Courtesy of Dr. Farshid Guilak