Welcome everyone to Episode 96 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter.
The Science Round Up
For this week’s round-up, STEMCELL would like to introduce Connexon’s three immunology newsletters: Immunology of Infectious Disease News, Human Immunology News, and Immune Regulation News. As with all of Connexon’s 20 weekly science newsletters, these free emails are compiled by field experts, who spend their days scouring the latest research, news, events, and jobs in various fields of cell biology. They do the digging so you can spend more time doing the science. Visit www.connexoncreative.com to subscribe.
This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- DNA’s role in life and death.
- Do it yourself vaccinations?
- Stats to help prevent child gun violence.
- Structure of new Alzheimer’s protein.
- Stem cell tourism needs tighter control.
- Guiding neural stem cells with electric stimulation.
- New in vitro model to test colon cancer drugs.
The interview with Dr. Robert Hancock
To kick off the interview portion of this episode, STEMCELL Technologies presents its product line called ImmunoCult™ that has been specifically developed for the activation, expansion and differentiation of immune cells:
- The ImmunoCult products can be used to activate, expand and differentiate T cells.
- There are also ImmunoCult products designed to generate monocyte-derived macrophages or dendritic cells.
- To learn more about ImmunoCult™ cells please visit immunocult.com
For the interview portion of the show, The Stem Cell Podcast and STEMCELL Technologies welcome Dr. Robert Hancock. Dr. Hancock is a Professor of Microbiology & Immunology, UBC, and a Canada Research Chair in Health and Genomics. Bob has published more than 660 papers and reviews, and has 50 patents awarded. The fundamental interest of Dr. Hancock and his laboratory is in designing new therapeutic strategies to treat infections in the light of increasing antibiotic resistance coupled with a dearth of new antibiotic discovery. Recently his team and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with the human immune system. The researchers used a combination of gene editing and stem cell technologies to make the model. The results, reported in Nature Communications, identify novel drug targets for the sexually transmitted disease.
After the interview, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
DNA Plays a Role in Birth and Death – This article reports that some gene versions stuck around because fertility advantage outweighs heart disease risk.
Do It Yourself Vaccinations? – According to this article, Band-Aid‒like patch studded with dissolving microneedles can safely and effectively deliver a dose of influenza vaccine.
Stats to Help Prevent Gun Injury in Children – This article reports that new numbers on firearm deaths and injuries provide most in-depth look yet at impact of firearm violence on children.
Scientists Have Uncovered the Atomic Structure of a Key Alzheimer’s Protein for The First Time – In this article, scientists have revealed the chemical structure of one of the key markers of Alzheimer’s disease, capturing high-resolution images of the abnormal tau protein deposits suspected to be behind Alzheimer’s and other neurodegenerative conditions.
‘Stem-Cell Tourism’ Needs Tighter Controls, Say Medical Experts – According to this article, stem-cell tourism involving patients who travel to developing countries for treatment with unproven and potentially risky therapies should be more tightly regulated.
Guiding Neural Stem Cells with Electrical Stimulation – This article shows that when scientists applied electric current to human neural stem cells injected into rats’ brains, the cells moved toward the animals’ subventricular zone and lateral ventricle, instead of toward their olfactory bulb, the default destination.
New In Vitro Model to Test Drugs for Colon Cancer – According to this article, the first-ever “disease in a Petri dish” platform that models human colon cancer derived from stem cells has been developed by Weill Cornell Medicine investigators, allowing them to identify a targeted drug treatment for a common, inherited form of the disease.
Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma – In this article, researchers used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in glioblastoma stem-like cells (GSCs).
Photo Reference: Courtesy of Dr. Robert Hancock