Happy Thanksgiving everyone and thanks for tuning in to Episode 32: Parkinson’s Cell Therapy Featuring Dr. Malin Parmar. Please be sure to go to stemcellpodcast.com and enter your name and email address to win a free SCP t-shirt. As always we start the show with our science round up sponsored by Thermo-Fisher. We spend 20 minutes going over what’s hot in the literature and talk about topics such as a stem cell cure for bubble boy disease, the discovery of new sub atomic particles, a new role for nail stem cells, stem cells that alleviate seizures, new insights identifying a “homosexual” gene region, and a study showing that looking down at your phone constantly can lead to problems with your neck. We then bring on Dr. Malin Parmar to talk about her latest paper in Cell Stem Cell regarding Parkinson’s disease. This paper is very important and made main stream news everywhere. Yosif and I then end the show with a rant about going over allotted time in presentations. Enjoy and Happy Thanksgiving.
Resources, Links and Research Papers Mentioned In This Session Include:
CERN’s Large Hadron Collider Adds Two New Subatomic Particles to the List – This article reveals that CERN’s researchers have added two new subatomic particles that are six times as massive as protons.
Brain Structure Rediscovered – This article describes how a Stanford graduate student Jason Yeatman has discovered what he thought was a new brain structure, known as the vertical occipital fasciculus (VOF), and later finds out that it was actually originally discovered in the late 19th century and got lost from the literature for more than 100 years.
Texting Creating ‘Text Neck’ Epidemic, Doctors Say – This article warns us that hunching over your smartphone can cause back pain, posture problems.
Alcoholism Damages Brain’s White Matter, Scans Show – This article points out that alcoholism damages white matter throughout the brain and this damage can be detected with brain scans according to the researchers.
Beat Deafness: A Man Lost in Musical Time – This article identifies the first documented beat deafness, a condition in which a person can’t feel music’s beat or move in time to it.
The Fault in Our Stars Might Be A Virus -This article describes how the starfish on the western coast of North America started wasting away, a condition known as sea star wasting syndrome (SSWS) potentially caused by a new virus called sea star-associated densovirus or SSaDV.
Stupidity Virus’ Lives In People’s Throats, Crosses Over From Algae In Lakes – This article shows how a virus commonly found in algae somehow made its way into people’s throats, reducing their ability to perform certain tasks.
Homosexuality is Genetic: Strongest Evidence Yet – In this article, scientists have found even more evidence that sexual orientation is largely determined by genetics, not choice.
Why Killing Babies Makes Testicles Grow – This article reports that nearly half of mammal species surveyed in a new study practice infanticide and scientists believe this leads to larger testicles in males.
Scientists Develop Barcoding Tool for Stem Cells – This article is about the new technology that tracks descendants of different stem cells or progenitor cells.
Eradicating Malaria: How Parasites’ Genetic ‘Barcodes’ Can Stop the Spread – According to this article, identifying the geographic origin of malaria outbreaks could help prevent and speed up the eradication of the disease.
How Cartilage Cells Sense Forceful Injury – In this article, scientists have found a substance in the tarantula venom that could block the channels responsible for cartilage cell death.
Bubble Boy’ Disease Cured With Stem Cells – This article reports that researchers have treated more than two dozen patients with a treatment made from their own bone marrow cells.
Female Stem Cells Could be Better for Heart Repair, Disease Treatment – This article suggests that female stem cells derived from animal muscle tissue, generated more muscle fiber and survived better when repairing injured cells according to a team of researchers.
Bifunctional Ectodermal Stem Cells Around the Nail Display Dual Fate Homeostasis and Adaptive Wounding Response Toward Nail Regeneration – This article discusses the regenerative potential of skin appendages particularly the nails following injury.
Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex – This article proposes that the conversion of nonneuronal cells into induced neurons can be an innovative strategy toward brain repair.
hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice – This article focuses on the study of hPSC-derived maturing GABAergic interneurons as a potential support to restorative cell therapy for epilepsy.
SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts – This article shows that mismatched mitochondria in nuclear-transfer-derived embryonic stem cells (NT-ESCs) possess alloantigenicity and are subject to immune rejection.
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence – This article determines that proinflammatory signaling, in the absence of infection, is utilized by the developing embryo to generate the lineal precursors of the adult hematopoietic system.
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain – According to the article, the myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry
Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease – This article shows the comprehensive preclinical assessment of hESC-derived midbrain dopamine neurons in a rat model of Parkinson’s disease.
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