Welcome everyone to Episode 95 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter.
The Science Round Up
For this week’s round-up, STEMCELL Technologies introduces Pulmonary Cell News. Covering everything lung, from COPD to CF to cancer, Pulmonary Cell News keeps readers current with the latest news, research, policy, events and jobs relevant to the lung research community. Check out Pulmonary Cell News and the rest of Connexon’s 20 science newsletters, all of which are provided by STEMCELL Technologies, at www.pulmonarycellnews.com
This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- A new, see through frog.
- Mechanism for cause of Parkinson’s.
- A protein responsible for preeclampsia in moms.
- Clinical trials to begin with cells derived from Human ES Cells in China.
- Compound in grapes can kill colon cancer stem cells.
- Stem cell scientist to run for congress in California?
- Stem cells to understand chlamydia.
The interview with Dr. Darrell Kotton
In the interview portion of this episode, STEMCELL Technologies brings you the Flyer: PneumaCult-Ex Plus. This flyer provides an overview of the new and improved workflow to culture human primary airway epithelial cells at the air-liquid interface (ALI), using PneumaCult-Ex Plus for expansion and PneumaCult-ALI for differentiation.
- Increased Expansion: More population doublings at each passage
- Sustained ALI Differentiation Potential: Maintain morphological and electrophysiological characteristics even after extended passaging
- Stem cell podcast listeners can find get more technical resources at pneumacult.com
For the interview portion of the show, The Stem Cell Podcast and STEMCELL Technologies welcome Dr. Darrell Kotton to the show. Dr. Kotton is a David C. Seldin Professor of Medicine and works as the Director in the Center for Regenerative Medicine of Boston University and Boston Medical Center. Dr. Kotton’s research focuses on stem cell biology and gene therapy related to lung injury and repair. Dr. Kotton’s laboratory currently utilizes several stem cell populations, including bone marrow-derived stem cells and embryonic stem cells in order to develop novel stem cell-based therapies for lung disease. In addition, Dr. Kotton specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors.
After the interview, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
A Newly Discovered See Through Frog – In this article, a newly discovered glass frog from Ecuador’s Amazon lowlands (Hyalinobatrachium yaku) has a belly so transparent that the heart, kidneys and urine bladder are clearly visible.
A Possible Mechanism to The Cause of Parkinson’s Disease – According to this article, in a blood test, immune cells called T cells became activated when exposed to the protein in about 40 percent of Parkinson’s patients.
A Protein Made by The Fetus May Lead to Preeclampsia in Moms – This article reports that in some women, the pregnancy condition preeclampsia, which can cause blood pressure to soar, may be triggered by DNA variations carried by the fetus.
How Facial Recognition Changes Wasp Brain – In this article, biologist Ali Berens of Georgia Tech and her colleagues set up recognition exercises of faces and basic patterns for P. fuscatus wasps and P. metricus wasps — a species that doesn’t naturally recognize faces but can be trained to do so in the lab.
Clinical Trial to Begin with Cells Derived from Human Embryonic Stem Cells – This article reports that surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson’s disease and inject 4 million immature neurons derived from human embryonic stem cells into their brains.
Compound in Grapes Can Kill Colon Cancer Stem Cells – According to this article, the compounds — resveratrol —which are found in grape skins and seeds, could also eventually lead to treatments to help prevent colon cancer, said Jairam K.P. Vanamala, associate professor of food sciences, Penn State.
Stem Cell Scientist to Run for Congress – This article reports that stem-cell researcher Hans Keirstead, 50, announced that he will try to unseat California’s Rep. Dana Rohrabacher.
Using Stem Cells to Understand How Chlamydia Does Its Damage – In this article, using a gene-editing tool called CRISPR/Cas9, the researchers are able to alter the properties of white blood cells in specific ways to see how chlamydia bacteria are able to penetrate and overwhelm cells, according to microbiologist Robert Hancock of the University of B.C.
Photo Reference: Courtesy of Dr. Darrell Kotton