Welcome everyone to Episode 104 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter.
The Science Round Up
For this week’s round-up, STEMCELL Technologies would like to share Hematopoiesis News, another one of Connexon’s 20 weekly science newsletters. Hematopoiesis News is free, and keeps readers up to date on the latest research, events, science news, policy and jobs in the hematology world. Subscribe at www.hematopoiesisnews.com.
This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- E-cigarettes increase likelihood of smoking.
- 9 million people died from pollution in 2015.
- Laws to protect athletes from concussion having an impact.
- Inbreeding impairs reproductive success.
- Method to accelerate maturation of stem cell derived neurons.
- Mutation plus UV causes skin cancer.
- Naked mole rats have stable epigenomes.
- Generation of a motor nerve organoid from stem cells.
The interview with Dr. Chad Cowan
In the interview portion of this episode, STEMCELL Technologies would like to invite you to watch a webinar presentation by Chad Cowan of Harvard University, titled “Investigating Metabolic Disease with Human Pluripotent Stem Cells.”
Chad discussed using genome editing to model metabolic diseases, with the aim of filling in the gap between fundamental biology and clinical therapies. Watch this webinar to learn how to use CRISPR/Cas system in human pluripotent stem cells.
In the webinar, Chad discussed:
- Applications of modified human pluripotent stem cells in modeling metabolic disease
- Differentiation of hepatocytes and adipocytes
- Watch the webinar at stemcell.com/cowan
For the interview portion of the show of the show, The Stem Cell Podcast and STEMCELL Technologies welcome Dr. Cowan. Chad is a principal investigator and Associate Professor in department of Stem Cell and Regenerative Biology at Harvard University. Chad joins the hosts to talk about CRISPR and its uses with stem cell biology to study disease.
After the interview, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
E-Cigarettes Can Lead Teens to Higher Smoking Rates in Teens – According to this article, teens who vaped liquids containing higher concentrations of nicotine reported heavier and more frequent smoking and vaping six months later.
9 Million People Died from Pollution in 2015 – This article reports that in the most severely polluted countries, 25 percent of premature deaths could be attributed to pollution, especially in the air.
Laws to Protect Athletes from Concussion Dangers Has an Impact – According to this article, more than 2½ years after the laws to protect young athletes against the dangers of concussions went on the books, repeat concussions began to decline among high school athletes.
Inbreeding Impairs Reproductive Success – In this article, mating with a close relative, known as inbreeding, reduces human evolutionary fitness — measured by the ability to produce offspring.
Method to Accelerate Maturation of Neurons Derived from Stem Cells – This article reveals that hydrogel can be used as a scaffold for engineering artificial brain tissue and promotes the development of neurons.
Mutation Plus Sun Tanning (Really UV Exposure) Causes Skin Cancer – In this article, a group of scientists based at Cornell University now report that melanoma may arise from melanocyte stem cells (MCSCs), specifically, MCSCs that have become “melanoma competent” because they have accumulated a sufficient number of genetic mutations.
Naked Mole Rat Cells Have a Stable Epigenome That Resists iPSC Reprogramming – In this article, researchers observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than that of mouse fibroblasts.
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons – According to this article, to build an organoid mimicking developing nerve tissue, researchers employed a strategy that allowed the neurons to follow the cell-intrinsic axon growth and fasciculation programs with minimal intervention.
Photo Reference: Courtesy of Dr. Chad Cowan