Wow, 40 episodes in the books, and we have another great episode for you. Please make sure you go to StemCellPodcast.com and sign up for our newsletter to get the latest episode and all the paper links emailed directly to you. In today’s episode we start off with our science round up brought to you by Thermo Fisher where we discuss a range of topics including, stem cell research in Oklahoma is now illegal, autism and the link to better cognitive ability, a new gene that regulates mouse fertility, stem cells as a toll to screen drug side effects, making cartilage from stem cells, a new study looking at the genomes of a 1000 autistic people, and what happens to stem cells in the brain as we age. Then we bring on our guest, world-renowned geneticist, Dr. Fred Alt from Harvard Medical School to talk about his latest paper in Nature Biotechnology where he describes a novel method to detect off target effects of gene editing technology. Then we finish off the show with a rant on USB cables. Enjoy.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries and/or an avenue for discussion. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
False Memories Implanted Into The Brains Of Sleeping Mice – According to this article, by directly manipulating the brains of sleeping mice, researchers tricked the animals into thinking they had received a reward at a specific place when they wake up.
Autism Genes Linked To Higher Intelligence: Treading A Fine Line Between Intellectual Disability And Superiority – In this article, a comprehensive study conducted shows that genetic variation, which increases risk for autism, is associated with better cognitive ability in non-autistic individuals.
Left or Right? The Brain Knows Before You Move – This article reports that scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
Mutation May Cause Early Loss Of Sperm Supply – In this article, Brown University biologists have determined how the loss of a gene in male mice results in the premature exhaustion of their fertility.
Sobering Effect Of The Love Hormone – According to this article, oxytocin, sometimes referred to as the ‘love’ or ‘cuddle’ hormone, prevents alcohol from accessing specific sites in the brain that cause alcohol’s intoxicating effects, sites known as delta-subunit GABA-A receptors.
Tapping Into Beer’s Therapeutic Potential – This article describes the study conducted by Chinese researchers on xanthohumol, a compound found in hops that prevented the brain cells from dying and also increased cell production of several antioxidants that counteracted oxidative damage.
Severe Depression Linked With Inflammation In The Brain – This article shows that there was a significant inflammation in the brains of the people with depression, and the inflammation was most severe among the participants with the most severe depression.
Ghrelin Hormone Supplement Increases Sex Drive – According to this article, new studies have found that a supplement of ghrelin – the “appetite hormone” – increased the sexual activity of mice.
Diabetes In Rats Treated With Engineered Probiotic – In this article, Cornell researchers have engineered human lactobacilli, a common gut bacteria, to secrete a protein called Glucagon-like peptide 1 (GLP-1) which may help people control diabetes.
Do You Have The ‘Smart Gene’ That Also Helps You Live Longer? – In this article, researchers have discovered that a KL-VS variant of the Klotho gene associated with longevity has some added benefits: improved learning and a better memory.
Largest-Ever Autism Genome Study Finds Most Siblings Have Different Autism-Risk Genes – This article reveals that the disorder’s genetic underpinnings are even more complex than previously thought: Most siblings who have autism spectrum disorder (ASD) have different autism-linked genes.
Wide House Passage Of Embryonic Stem Cell Research Ban In Oklahoma Despite Concerns – This article reports that the House overwhelmingly passed legislation Monday designed to prevent embryonic stem cell research in Oklahoma.
Limited Self-Renewal Of Stem Cells In The Brain – This article describes that the self-renewal rate of the stem cells is however limited, explaining why their number drops over the course of a lifetime.
New Test Uses Human Stem Cells to Identify Drug Side Effects – In this article, scientists have developed a test that uses cells from a single donor’s blood to predict whether a new drug will cause a severe reaction in humans.
Lung Cancer Stem Cell Therapy To Be Trialled In UK – This article reports that trial will involve 56 patients in UK with metastatic lung cancer who will undergo treatment using genetically modified bone marrow stem cells.
Some Breast Cancers Are Like ‘Stem Cells Gone Bad’ – According to this article, testing breast cancer cells for how closely they resemble stem cells could identify the most aggressive cases of the disease.
Stem Cells Reduce MS Brain Damage – This article describes in what could herald a major advance in treating multiple sclerosis, brain damage was significantly reduced in patients getting stem cell transplants, compared to a control group.
In Vivo Therapeutic Potential of Mesenchymal Stromal Cells Depends on the Source and the Isolation Procedure – According to this article, findings indicate that the choice of Mesenchymal Stromal Cells (MSC) source and purification protocol is critical in determining the therapeutic potential of these cells and warrant the standardization of an optimal MSC isolation procedure in order to select the best conditions to move forward to more effective clinical experimentation.
Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs – This article describes how researchers developed a method for generating scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs).
Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade – This article shows that sex steroid ablation (SSA) induces hematopoietic and lymphoid recovery by functionally enhancing both hematopoietic stem cells (HSCs) self-renewal and propensity for lymphoid differentiation through intrinsic molecular changes.
Scientists Discover Why Some Heart Tissue Turns Into Bone – In this article, researchers have used human cells to discover how blood flow in the heart protects against the hardening of valves in cardiovascular disease and identified a potential way to correct this process when it goes wrong by flipping the switch on just a handful of genes.
Stem Cells Lurking in Tumors Can Resist Treatment – According to this article, malignant tumors contain stem cells, prompting worries among medical experts that the cells’ transformative powers help cancers escape treatment.
Photo Reference: Courtesy of Dr. Alt