Thanks for tuning in to Episode 56, Glia featuring Dr. Steven Goldman. This and all of our episodes are sponsored by Thermo-Fisher Scientific. Go to stemcellpodcast.com for all of our episodes and to sign up for our newsletter. We begin as always with the #SciRoundUp and discuss the latest science and stem cell news including:
- Diamonds can detect cancer?
- A vaccine for AIDS brought to the clinic
- An “in womb” stem cell trial to begin?
- Stem cell burgers coming soon
- Stem cells to alleviate dementia
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on stem cell expert Dr. Steven Goldman from the University of Rochester to talk about glial cells and his work using stem cells to model and fix diseases like Multiple Sclerosis using Neural Stem Cells. Finally, we close the show with our signature rant on: “when someone tells you, you look tired.” Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Can A Cancer Drug Reverse Parkinson’s Disease And Dementia? – According to this article, a drug that’s already approved for treating leukemia appears to dramatically reduce symptoms in people who have Parkinson’s disease with dementia, or a related condition called Lewy body dementia.
Study Shows Antioxidant Use May Promote Spread Of Cancer – In this article, a team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with cancer.
Sitting For Long Periods Is No Worse For Your Health Than Standing, Study Claims – This article reveals that prolonged sitting doesn’t appear to be killing you any faster than standing.
Does fungus cause Alzheimer’s? – In this article, researchers discover traces of fungus in the brains of Alzheimer’s sufferers.
Schizophrenia Symptoms Linked To Features Of Brain’s Anatomy? – This article describes how Washington University psychiatrist C. Robert Cloninger, MD, PhD, and fellow researchers have matched certain behavioral symptoms of schizophrenia to features of the brain’s anatomy using advanced brain imaging.
Can Diamonds Detect Cancer? – According to this article, a new study out of Australia found that synthetic versions of diamonds to be effective at detecting early-stage cancerous tumors through magnetic resonance imaging (MRI).
Armed Malaria Protein Found To Kill Cancer Cells – In this article, a new type of cancer therapy based on seemingly unrelated elements of malaria and cancer is showing promise for development.
Ebola Found In The Semen Of Some Men Nine Months Later – This article reveals that some men still have fragments of Ebola virus in their semen nine months after first showing symptoms of the virus.
Larger Brains Do Not Lead To High IQs – This article shows that brain volume plays only a minor role in explaining IQ test performance in humans but rather brain structure and integrity appear to be more important as a biological foundation of IQ.
AIDS Pioneer Finally Brings AIDS Vaccine To Clinic – According to this article, Robert Gallo’s team has been developing a vaccine with an unusual method of protection for 15 years and is now launching the first clinical trial of it in collaboration with Profectus BioSciences, a biotech that spun off from Institute of Human Virology (IHV) recently.
Newly Unraveled Dynamic Structure Of DNA Could Pave Way For Better Medicines – This article reports that an improved understanding of the appearance of the DNA – shown in research to have a dynamic, constantly wiggling and morphing nature – is believed to help scientists in producing new antibiotics, more effective chemotherapies and better drugs.
First ‘In Womb’ Stem Cell Trial To Begin – This article announced the first clinical trial injecting foetal stem cells into babies that are still in the womb.
Scientists Produce Beef From Cow’s Stem Cells: Lab-Grown Burgers Could Be On The Menu By 2020 – In this article, Prof. Mark Post who created the lab-grown burger made from stem cells in his lab facility in Maastricht, The Netherlands is developing the technology for mass production expressed confidence in having the novel product on the market in five years.
Scottish Researchers are 3D Printing Extremely Delicate Stem Cells – According to this article, the team at Heriot-Watt led by Dr. Will Shu, at the University’s School of Engineering and Physical Sciences (EPS), have the distinction of being the first group to 3D print with stem cells, using a valve-based technique.
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation – In this article, researchers find that the cellular transcriptomes of cells grown in three different conditions: serum, 2i, and the alternative ground state a2i, are distinct, with 2i being the most similar to blastocyst cells and including a subpopulation resembling the two-cell embryo state.
Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism – This article describes how striatal transplantation of NSCs into aged α-syn transgenic mice significantly improves performance in multiple cognitive and motor domains.
Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis – In this article, researchers demonstrate that AKT1-activated bone marrow endothelial cells (BMEC-Akt1) have a unique transcription factor/cytokine profile that supports functional hematopoietic stem cells (HSCs) in lieu of complex serum and cytokine supplementation and the transplantation of BMEC-Akt1 cells enhanced regenerative hematopoiesis following myeloablative irradiation.
Crestospheres: Long-Term Maintenance of Multipotent, Premigratory Neural Crest Stem Cells – This article shows the conditions that enable maintenance of neuroepithelial “crestospheres” that self-renew and retain multipotency for weeks.
Model Of Fibrolamellar Hepatocellular Carcinomas Reveals Striking Enrichment In Cancer Stem Cells – In this article, researchers present a transplantable tumour line, maintained in immune-compromised mice, and validate it as a bona fide model of human fibrolamellar hepatocellular carcinomas (hFL-HCCs) by multiple methods.
Photo Reference: Courtesy of Dr. Steven Goldman