Welcome everyone to Episode 91 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. In this episode, we talk with Dr. Rick Horwitz and Dr. Graham Johnson of the Allen Institute for Cell Science in Seattle
The Science Round Up
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This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- The “March for Science.”
- HPV Vaccine as a Cancer Prevention Needs to be Emphasized.
- Neuron rewiring can lead to depression.
- Zika hangs out in out the body.
- Is CIRM on its last leg?
- CRISPR editing to fight arthritis.
- CRISPR and stem cells identify novel chlamydia targets.
- Activating stem cells for quicker healing.
The interview with Dr. Rick Horwitz and Dr. Graham Johnson
The Stem Cell Podcast and STEMCELL Technologies are very pleased to be welcoming Dr. Rick Horwitz and Dr. Graham Johnson to the Stem Cell Podcast. Rick spent the past 15 years in the Department of Cell Biology, as Harrison Distinguished Professor and University Professor, at the University of Virginia, School of Medicine, where his lab investigated the mechanisms of cell migration and dendritic spine morphogenesis. He also served for 10 years as the Director of the Cell Migration Consortium: an NIH-funded multi-institutional, multi-disciplinary collaboration for studying cell migration in its many biological and pathological contexts. He is now the Executive Director of the Allen Institute for Cell Science in Seattle, WA. STEMCELL Technologies is very proud to be providing the Allen Institute for Cell Science with the specialized cell culture and differentiation medium required to maintain and validate their commercially-available iPS cell lines. The STEMdiff Trilineage Differentiation Kit provides a simple culture assay to functionally validate the ability of new or established human ES and iPS cell lines to differentiate to the three germ layers: mesoderm, endoderm, and ectoderm. To learn more about STEMCELL’s Trilineage Differentiation Kit, visit: www.stemcell.com/trilineage.
Graham is a computational biologist and Certified Medical Illustrator. He graduated from The John Hopkins School of Medicine, Department of Art as Applied to Medicine in 1997, and received his PhD from The Scripps Research Institute in La Jolla, CA, working in Art Olson’s Molecular Graphics Lab. He then moved to the California Institute for Quantitative Biosciences at UCSF where he focused on generating, simulating and visualizing molecular models of cells with his lab’s Mesoscope project. At the Allen Institute for Cell Science, Graham and his team compile experiment and imaging data into multi-scale, spatiotemporal and interactive models of the cell – to create the Animated Cell Explorer. After this fascinating conversation, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
A March for Science Happened – According to this article, scientists had to engage and take their demands to political leaders and policymakers, so they stood for hours on a sodden National Mall and then marched through puddles to Capitol Hill.
HPV Vaccine as a Cancer Prevention Needs to be Emphasized – This article reports that in the United States, HPV vaccination rates lag for girls and boys mainly because the message that the vaccine prevents cancer isn’t getting out there.
All Crossed Up-Neuron Miswiring Can Lead To Depression – In this article, researchers have pinpointed a gene called Pcdhαc2 that keeps important brain cells in mice from crossing their wires, providing a possible link between brain wiring and mood disorders like depression.
Zika Virus Hangs Out in Your Body – This article reveals that weeks after the virus disappears from the bloodstream, it still lingers in the lymph nodes and the central nervous system of rhesus monkeys.
CIRM is on Its Last Leg – According to this article, major investment in regenerative medicine enters its last stage — and the money might run out before treatments are ready.
CRISPR Editing to Fight Arthritis – In this article, scientists have rewired stem cells’ genetic circuits known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy) to produce an anti-inflammatory arthritis drug when the cells encounter inflammation.
CRISPR and Stem Cells Identify Novel Chlamydia Drug Targets – This article reports that researchers at the Wellcome Trust Sanger Institute and their colleagues at the University of British Columbia have developed a novel method for studying how the bacterium Chlamydia trachomatis interacts with the human immune system.
Activating Stem Cells for Quicker Healing – According to this article, recent research, led by assistant professor of stem cell biology and regenerative medicine at the University of South Carolina Joseph T. Rodgers, has found a way to increase the body’s ability to heal after injury.
Photo Reference: Courtesy of Dr. Rick Horwitz and Dr. Graham Johnson