Welcome everyone to Episode 98 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
For this week’s round-up, STEMCELL Technologies is excited to remind listeners about Neural Cell News, one of Connexon’s most popular newsletters. Neural Cell News covers the latest research every week, including neural development and neuroregeneration, neural signaling and synaptic plasticity. In addition, research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, MS, Alzheimer’s, ALS, and various brain cancers, as well as brain damage is covered, plus Industry News, Events and Jobs in the neuroscience field are included every week. Subscribe for free at www.neuralcellnews.com
This week, in the world-famous Science Round Up, we discuss the latest science/stem cell news including:
- Gene editing of human embryos.
- Mutation in mice affects littermate behavior.
- 1 in 3 Americans take opioids.
- Stem cell derived brain implants can slow aging.
- ONC201 may inhibit cancer stem cell self-renewal.
- New stem cell derived insulin producing cells.
The interview with Dr. Dustin Wakeman
In the interview portion of this episode, STEMCELL Technologies brings you STEMdiff Cerebral Organoid Kit – for culturing cerebral organoids. These cutting-edge 3D ‘mini-brains’ offer a more physiologically relevant model that recapitulates human brain development in vitro:
- Allow researchers to explore challenging age-old questions in new ways
- Can also ask new questions not possible with previous models
- Kit is based on the published formulation by Madeline Lancaster and Jurgen Knoblich
- Streamlined and optimized with easy-to-follow protocol
- It’s serum-free and allows you to culture cerebral organoids from human ES cells and iPS cells
- For more information about the STEMdiff Cerebral Organoid Kit, please visit stemcell.com/STEMdiffCO
For the interview portion of the show, The Stem Cell Podcast and STEMCELL Technologies welcome Dr. Dustin Wakeman. Dustin is Senior Research Scientist at RxGen & Adjunct Assistant Professor at Yale School of Medicine. Dr. Wakeman focuses his career on determining the long-term therapeutic value of stem cell therapy in neurodegenerative disorders. His interests include stem cell-based therapeutics, disease modeling, neural transplantation, and morphological and molecular changes in aging and neurodegenerative diseases including Parkinson’s, Huntington’s, Alzheimer’s and more.
After the interview, we close the show with a signature SCP rant.
Resources, Links and Research Papers Mentioned in This Session Include:
Gene Editing of Human Embryos Gets Rid of a Mutation That Causes Heart Failure – According to this article, molecular scissors known as CRISPR/Cas9 corrected a gene defect that can lead to heart failure.
Mice with A Mutation Linked to Autism Affect Their Littermates’ Behavior – This article suggests that genetically normal littermates behave like mice that carry an autism-related mutation, despite not having the mutation themselves.
One in Three U.S. Adults Takes Opioids, And Many Misuse Them – In this article, National Survey on Drug Use and Health reports that in an in-person survey of more than 50,000 people, researchers estimated that 91.8 million, or 37.8 percent, of adults used prescription opioids in 2015.
Stem Cell Brain Implants Could ‘Slow Ageing and Extend Life’, Study Shows – This article reveals that scientists have slowed down the ageing process by implanting stem cells into the brains of animals, raising hopes for new strategies to combat age-related diseases and extend the human lifespan.
ONC201 May Inhibit Cancer Stem Cell Self-Renewals by Altering Their Gene Expression – According to this article, ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.
Researchers Develop New Way to Develop Purer Insulin-Producing Stem Cells – In this article, researchers have found that the cell surface protein glycoprotein 2 (GP2) allowed them to isolate the pancreatic endoderm cells (PECs); enabling them to get a purer sample of cells which could increase their effectiveness and safety when implanted into humans.
Photo Reference: Courtesy of Dr. Dustin Wakeman