Dr. Lydia Finley is an Assistant Member of the Cell Biology Program at Memorial Sloan Kettering Cancer Center. The Finley lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. She talks about the metabolic profiles and needs of different cell types, her lab’s discovery of an alternate TCA cycle, and how track and field led her to pursue metabolism research.
Dr. Alejo Rodriguez-Fraticelli is a Group Leader at the Institute for Research in Biomedicine in Barcelona, where his team studies stem cell memory and epigenetics in hematopoiesis, immunity, and leukemia. He talks about setting up a new lab as a “playground for scientists,” how cancer is the “evil twin” of regeneration, and advanced methods for lineage tracing.
Dr. Nazish Sayed is an Assistant Professor of Surgery at the Stanford Cardiovascular Institute. His lab is focused on developing new technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. He talks about developing an inflammatory aging clock, using iPSC-derived endothelial cells to run a clinical trial in a dish, and his experience as a cancer patient.
Dr. Paul Knoepfler is a Professor in the Department of Cell Biology and Human Anatomy, the Genome Center, and the Comprehensive Cancer Center at the University of California, Davis. His lab is interested in the epigenetics of stem cells and cancer, and uses cutting-edge molecular, cellular, and developmental biology methods as well as genomic and gene editing technologies to answer key questions in these areas of research.
Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.