Ep. 221: “Metabolism and Cell Fate” Featuring Dr. Lydia Finley
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Dr. Lydia Finley is an Assistant Member of the Cell Biology Program at Memorial Sloan Kettering Cancer Center. The Finley lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. She talks about the metabolic profiles and needs of different cell types, her lab’s discovery of an alternate TCA cycle, and how track and field led her to pursue metabolism research.
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The Stem Cell Science Round Up
Chemical Induction of Mouse Totipotent Stem Cells – Researchers used three small molecules to induce totipotent stem cells from mouse PSCs.
Aneuploidy in T Cell Therapy – Scientists found that aneuploidy and chromosomal truncations are frequent outcomes of CRISPR–Cas9 cleavage.
Modeling Nipah and Hendra Virus Infections – Researchers modeled viral infection of the human vasculature in PSC-derived artery and vein cells.
A Gatekeeper Transcription Factor for Pancreatic Differentiation – CRISPR screening showed that HHEX suppresses liver differentiation to promote pancreatic lineage commitment.
Photo Reference: Courtesy of Dr. Lydia Finley