Ep 141: “iPSC-Derived Myogenic Progenitors” Featuring Dr. Rita Perlingeiro
Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies.
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Resources and Links
New CAR T-Cell Therapy Less Toxic – A Phase I clinical trial has shown that a redesigned CAR T-cell molecule was less toxic and produced fewer side effects in patients, making the treatment safer.
Using MSCs to Engineer an HSC Niche – Researchers have identified genes in mesenchymal stem cells that enhanced the production of niche factors that could maintain hematopoietic stem cells in culture.
Generating Ovarian Cancer Organoids – Investigators developed a protocol for generating and expanding ovarian cancer organoids, and demonstrated their potential applications.
Stress-Resistant Muscle Stem Cells – Scientists have identified a population of muscle stem cells that resist radiation and are able to expand under severe stress.
Muscle Stem Cells Protected from Environmental Stress – The expression of a transcription factor has been shown to protect muscle stem cells against environmental stress caused by a toxic pollutant.
Photo Reference: Courtesy of Dr. Rita Perlingeiro