Ep. 153: “Signal Transduction in Stem Cells and Cancer” Featuring Dr. Stephane Angers
Dr. Stephane Angers is a Professor and Associate Dean of Research in the Leslie Dan Faculty of Pharmacy at the University of Toronto. He is an expert in the field of signal transduction, working to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and the large family of G protein-coupled receptors.
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The Stem Cell Science Round Up
First-Ever Map of the Developing Human Liver – Investigators have created the first-ever human developmental liver cell atlas, which provides insights into how the blood and immune systems develop.
Engineering Vascularized Brain Organoids – Scientists have developed a method to induce vasculature in brain organoids, improving oxygen and nutrient delivery and allowing them to live longer.
Improved Culture Method for Expanding Hematopoietic Stem Cells – Using a zwitterionic hydrogel, investigators achieved substantial expansion of human hematopoietic stem and progenitor cells, and may be used to improve the effectiveness of HSC therapies.
Using Tumor Organoids to Predict Chemo Response – Researchers have developed a method to test drugs in tumor-derived organoids to determine how a cancer patient will respond to chemotherapy.
Development of a Rectal Cancer Organoid Platform – The first human tumor-derived model for studying rectal cancer has been developed and was used to study the effects of chemoradiation.
Photo Reference: Courtesy of Dr. Stephane Angers