Ep. 165: “Tackling Heart Disease” Featuring Dr. Deepak Srivastava
Among his many appointments, Dr. Deepak Srivastava is the President of the Gladstone Institutes and the International Society for Stem Cell Research, and co-founder of Tenaya Therapeutics. His lab investigates the gene networks that guide cardiogenesis by developing models of heart disease using patient-derived iPSCs and CRISPR technology.
Featured Products and Resources:
- Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability
- STEMdiff™ Cardiomyocyte Media
The Stem Cell Science Round Up
Reconstructing the Human Developmental Clock – By using iPSCs to mimic signaling pathways active during early development, scientists have reconstructed the human segmentation clock to model somitogenesis.
Transition from Progenitor to Mature Adipocyte – Investigators have shown that platelet-derived growth factor receptors, which are markers of adipocyte progenitors, are cell-autonomous inhibitors of adipocyte differentiation.
Exploiting Vulnerabilities in Pancreatic Cancer – A senescence-inducing therapy has been shown to sensitize therapy-resistant pancreatic tumors to checkpoint blockade drugs by causing vascular remodeling.
Lessons in Graft Remodeling – Combining a clinical trial, computational studies and a sheep model, researchers have found that stenosis caused by tissue-engineered vascular grafts could resolve spontaneously, and provides insight for future graft design.
Photo Reference: Courtesy of Dr. Deepak Srivastava