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Ep. 191: “Laser-Based Cell Manipulation” Featuring Dr. Marinna Madrid

By April 20, 2021March 29th, 2023No Comments


Dr. Marinna Madrid is Co-Founder of Cellino, an early-stage biotechnology company seeking to make personalized, autologous cell therapies viable at large scale for the first time. Cellino’s platform combines label-free imaging and high-speed laser editing with machine learning to automate cell reprogramming, expansion, and differentiation in a closed cassette format, enabling thousands of patient samples to be processed in parallel in a single facility.

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The Stem Cell Science Round Up

Using IGF1 to Rescue HSCs from the Hallmarks of Aging – Researchers found that a decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging, and that direct stimulation with IGF1 could reverse this phenotype.

Krüppel-Like Factor 1 is Critical for Heart Regeneration in Zebrafish – Krüppel-Like Factor 1 stimulates new cardiomyocyte production by reprogramming gene networks that regulate cardiomyocyte differentiation and mitochondrial metabolism.

How Aneuploid Embryos Can Lead to Healthy Births – Scientists showed that mosaic embryos can be rescued through BMP4-dependent apoptosis of aneuploidy in the primary germ layers.

Patient-Derived Cervical Organoids  – Generated from a pap smear sample, cervical organoids can be used as an experimental platform for sexually transmitted infection and cervical cancer research.

Photo Reference: Courtesy of Dr. Marinna Madrid

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