Ep. 191: “Laser-Based Cell Manipulation” Featuring Dr. Marinna Madrid
Dr. Marinna Madrid is Co-Founder of Cellino, an early-stage biotechnology company seeking to make personalized, autologous cell therapies viable at large scale for the first time. Cellino’s platform combines label-free imaging and high-speed laser editing with machine learning to automate cell reprogramming, expansion, and differentiation in a closed cassette format, enabling thousands of patient samples to be processed in parallel in a single facility.
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The Stem Cell Science Round Up
Using IGF1 to Rescue HSCs from the Hallmarks of Aging – Researchers found that a decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging, and that direct stimulation with IGF1 could reverse this phenotype.
Krüppel-Like Factor 1 is Critical for Heart Regeneration in Zebrafish – Krüppel-Like Factor 1 stimulates new cardiomyocyte production by reprogramming gene networks that regulate cardiomyocyte differentiation and mitochondrial metabolism.
How Aneuploid Embryos Can Lead to Healthy Births – Scientists showed that mosaic embryos can be rescued through BMP4-dependent apoptosis of aneuploidy in the primary germ layers.
Patient-Derived Cervical Organoids – Generated from a pap smear sample, cervical organoids can be used as an experimental platform for sexually transmitted infection and cervical cancer research.
Photo Reference: Courtesy of Dr. Marinna Madrid