Ep. 208: “Translating Stem Cell Discoveries” Featuring Dr. Ilyas Singeç
Dr. Ilyas Singeç is the Director of the Stem Cell Translation Laboratory at the National Center for Advancing Translational Sciences, where he leads a group of scientists working to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies. He discusses the standardization of stem cell differentiation, high-throughput cell culture, personalized medicine, and the potential for biomanufacturing in space.
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The Stem Cell Science Round Up
Blastoid Implantation in Endometrial Organoids – Scientists generated blastoids, performed single-cell analysis of the trophectoderm, epiblast, and primitive endoderm, and implanted them into open-faced endometrial organoids.
Pancreatic Progenitor Implants for Type 1 Diabetes – Pancreatic endoderm cells implanted in patients with type 1 diabetes were well-tolerated and induced meal-regulated insulin secretion.
YAP Signaling in Dry Mouth – Stimulating YAP activity promotes regeneration of mouse and human salivary gland cells after injury.
Cardiac and Gut Tissues in Multilineage Organoids – Scientists developed a human multilineage iPSC-derived organoid that recapitulates cooperative cardiac and gut development and maturation.
Photo Reference: Courtesy of Dr. Ilyas Singeç