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Guest:
This special episode, created in partnership with the ISSCR Early Career Advisory Committee, features two rising leaders in stem cell research. Dr. Yifei (Simon) Miao, a Professor at the Chinese Academy of Sciences, discusses engineering vascularized organoids and integrating bioengineering approaches to build more physiologically relevant human tissues. Dr. Anca Pașca, an Assistant Professor at Stanford Medicine, explores how stem cell-derived brain organoids and assembloids are advancing our understanding of neonatal brain injury and neurodevelopmental disorders, with the goal of developing new therapies for vulnerable infants.
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The Stem Cell Science Round Up
Editing Early Human Development – Base editing of human embryos reveals that NANOG is essential for epiblast formation and human pluripotency.
Reprogramming Colorectal Cancer – Loss of GATA6 promotes colorectal cancer liver metastasis by driving multilineage cellular plasticity.
Precision Medicine for Pancreatitis – Patient-derived organoids identify chronic pancreatitis subtypes and reveal CFTR modulators as a potential treatment.
Tracking Heart Organoids – A wireless cantilever platform enables high-throughput measurement of contractile forces in human cardiac organoids.
Photo Reference: Courtesy of Drs. Yifei (Simon) Miao and Anca Pasca
