Welcome everyone to Episode 79 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter.
The Science Round Up
We begin with the world famous Science Round Up and discuss the latest science/stem cell news including:
- New antibody therapy for Zika.
- Single cell small RNA sequencing.
- President-Elect Trump and stem cells.
- Dedifferentiation of hepatocytes.
- Using video games to speed up brain research.
- Chromatin, stem cells, and cancer.
The interview with Dr. Alpa Mahuvakar
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on Dr. Alpa Mahuvakar Trivedi, a molecular biologist in the Department of Neurosurgery at University California San Francisco. Alpa and her team have recently published a paper on generating neural cells from stem cells to help pain and bladder function after spinal cord injury. After this we close the show with a signature Stem Cell Podcast rant. Enjoy!
Below are all of the papers mentioned on the show, should you wish to read them in more detail. You can also sign up for our newsletter below.
Resources, Links and Research Papers Mentioned in This Session Include:
What Does Trump Win Mean for US Science? – This article reports that many scientists have been laying out their concerns about the future of the US research community under a Trump administration.
Poor Diet in Pregnancy, Poor Heart Health for Infants – According to this article, mothers who don’t eat enough during pregnancy could give birth to babies with long-lasting heart problems.
Using A Video Game To Speed Up Alzheimer’s Research – This article describes the new game Stall Catchers where citizen scientists help Alzheimer’s researchers find stalls in brain blood vessels in mice.
Antibody Therapy for Zika Virus? – In this article, scientists have found that a single dose of a human antibody called ZIKV-117 can protect mice from death after Zika infection — and shield mouse fetuses from the virus’s damaging effects.
Trump and Embryonic Stem Cells – In this article, biomedical researchers are wondering what the Trump administration’s position is on embryonic stem cells research though he has vowed to “cancel every unconstitutional executive action, memorandum and order issued by President Obama.”
Single-Cell Sequencing of the Small-RNA Transcriptome – According to this article, researchers present a single-cell method for small-RNA sequencing and apply it to naive and primed human embryonic stem cells and cancer cells.
Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity – In this article, researchers report that a cocktail of small molecules, Y-27632, A-83-01, and CHIR99021, can convert rat and mouse MHs in vitro into proliferative bipotent cells, which we term chemically induced liver progenitors (CLiPs).
Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer – According to this article, stem cell differentiation induces chromatin remodeling at repetitive elements offering a permissive environment for Ewing sarcoma (a mesenchymally derived tumor) development.
Photo Reference: Courtesy of Dr. Alpa Mahuvakar