Ep. 146: “CRISPR-Based Modeling of Congenital Heart Disease in Patient iPSCs” Featuring Dr. Arun Sharma
Dr. Arun Sharma is a Senior Research Fellow in the Svendsen lab at Cedars-Sinai. His research focuses on the applications of iPSCs for studying cardiovascular biology, modeling diseases in a dish with genome editing technologies, and developing high-throughput platforms for screening drug toxicity and efficacy.
Featured Products and Resources:
- STEMdiff™ Cardiomyocyte
- Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability
Resources and Links
Regeneration Potential of Neonatal Mouse Heart – Researchers have shown that the regeneration capacity of the neonatal mouse heart is limited, suggesting that the processes of embryonic heart development and postnatal heart generation are distinct.
Guiding Human Development in a Dish– Scientists have developed a method for exposing human ESCs to gradients of key signaling molecules to mimic the early stages of embryonic development.
Immune Cells Invade Aging Brains – Investigators have found that T cells invade the brain of aged mice and inhibit the proliferation of neural stem cells.
Ethical Development of Stem-Cell Based Interventions – The authors address key ethical and policy challenges confronting the clinical translation of stem cell-based interventions.
Dopamine Replacement Trial for Parkinson’s Disease – A clinical trial is underway to assess the efficacy of transplanting PSC-derived dopamine-producing cells in Parkinson’s disease patients.
Photo Reference: Courtesy of Dr. Arun Sharma