Dr. Shuibing Chen is the Kilts Family Professor of Surgery at Weill Cornell Medicine. Her lab uses hiPSCs and ESCs for disease modeling and drug screening, with a focus on diabetes and infectious diseases such as Zika and SARS-CoV-2. She talks about her recent genome-wide association study in a dish, the role of philanthropic funding in stem cell research, and the role of industry partnerships in translational research.
Dr. Mingxia Gu is an Assistant Professor of Pediatrics at Cincinnati Children’s Hospital. Her lab’s goal is to develop novel therapies for the regeneration of the heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. She talks about developing lung organoids to study COVID-19, how multi-lineage organoids can mimic human tissues, and her lab’s motto to “move fast and break things.”
Dr. Nazish Sayed is an Assistant Professor of Surgery at the Stanford Cardiovascular Institute. His lab is focused on developing new technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. He talks about developing an inflammatory aging clock, using iPSC-derived endothelial cells to run a clinical trial in a dish, and his experience as a cancer patient.
Dr. Ru Gunawardane is the Executive Director at the Allen Institute for Cell Science. She leads a group of researchers creating a collection of high-quality gene edited stem cell lines to study cell organization and activities through live cell imaging. Dr. Kaytlyn Gerbin is a Scientist at the Allen Institute, whose work focuses on implementing cardiac differentiation methods and developing the cardiomyocyte pipeline using gene-edited hiPSCs. They discuss the Institute’s mission to understand the fundamentals of how cells work, how they generate their gene-edited stem cell lines, and their recent work tracking cell states in hiPSC-derived cardiomyocytes.
Dr. Christine Mummery is a Professor of Developmental Biology at the Leiden University Medical Center and the former President of the International Society for Stem Cell Research. She pioneered studies on cardiomyocytes from human embryonic stem cells and was among the first to inject them in mouse hearts after myocardial infarction. She talks about her recent research developing multi-lineage cardiac model systems like microtissues and organ-chips.