Dr. Boyang Zhang is an Assistant Professor of Chemical Engineering at McMaster University. His lab uses advanced biofabrication techniques to build human micro-tissue models for predictive drug discovery and to construct functional macro-tissues for tissue regeneration in patients. He talks about building microfluidic devices for biological applications and using machine learning to study organoid morphology. He also talks about his team’s high-throughput system for vascularizing tissue spheroids and his experience starting a company to commercialize this technology.
Dr. Shuibing Chen is the Kilts Family Professor of Surgery at Weill Cornell Medicine. Her lab uses hiPSCs and ESCs for disease modeling and drug screening, with a focus on diabetes and infectious diseases such as Zika and SARS-CoV-2. She talks about her recent genome-wide association study in a dish, the role of philanthropic funding in stem cell research, and the role of industry partnerships in translational research.
Dr. Paola Arlotta is the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University. She is interested in understanding the molecular laws that govern the birth, differentiation, and assembly of the human brain’s cerebral cortex. She talks about using organoids to study the genetics of autism. She also discusses single-cell sequencing of brain organoids and how to make single-cell sequencing methods and data more accessible.
Dr. Prisca Liberali is Senior Group Leader at the Friedrich Miescher Institute for Biomedical Research and an Assistant Professor at the University of Basel. Her research aims to understand the collective properties of organoid systems and their patterns, including how these systems allow systematic perturbation by established methods for modulating gene expression. She studies self-organization, symmetry breaking, intestinal organoid development, gastruloids, and mechanosensing mechanisms.
Dr. Ophir Klein is the inaugural Executive Director of Cedars-Sinai Guerin Children’s and the David and Meredith Kaplan Distinguished Chair in Children’s Health. He discusses his work on intestinal epithelium regeneration, which he will present at the “Tissue Fibrosis and Repair: Mechanism, Human Disease, and Therapies” Keystone Symposium taking place from June 12-16th in Keystone, Colorado. He also talks about mechanisms of tooth development, analyzing three-dimensional facial images to diagnose genetic syndromes, and how parasitic infections affect the intestinal stem cell niche.