Dr. Kelly McNagny is a Professor of Medical Genetics and Biomedical Engineering at the University of British Columbia. His research program is focused on hematopoietic stem cell biology, specifically in understanding the signaling networks that regulate stem cell differentiation and how these cells interact with their microenvironment. He talks about how hematopoietic stem cell differentiation is related to chronic inflammatory disorders, targeting glycosylation in solid tumors, and his international career path.
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Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.
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Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia.
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Guest: Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such…
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Guest: Dr. Josef Penninger is the Director of the Life Sciences Institute at the University of British Columbia and a Canada 150 Chair in Functional Genetics. He was previously the Scientific and Founding Director of…
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