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Dr. Alejo Rodriguez-Fraticelli is a Group Leader at the Institute for Research in Biomedicine in Barcelona, where his team studies stem cell memory and epigenetics in hematopoiesis, immunity, and leukemia. He talks about setting up a new lab as a “playground for scientists,” how cancer is the “evil twin” of regeneration, and advanced methods for lineage tracing.
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Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.
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Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia.
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Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell.
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Guest: Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such…
