Ep 143: “Cell Fate Decisions at Single-Cell Resolution” Featuring Dr. Bertie Göttgens
Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such networks cause leukemia. In this episode, he talks about his research and his groundbreaking paper that mapped mouse gastrulation and early organogenesis.
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New Neurons Form in Old Age, Even in People with Alzheimer’s – Researchers have shown that hippocampal neurons continue to form well into old age, as well as in individuals with mild cognitive impairments and Alzheimer’s disease.
Blocking an Inflammatory Protein Reverses Brain Aging – Blocking an inflammatory protein in brain cells reversed the effects of brain aging in old mice, and prevented signs of brain aging in young mice infused with old blood.
New Mechanism Identified for Blood Stem Cell Development – Researchers have discovered a new role for the epidermal growth factor receptor in regulating hematopoietic stem cell development.
Mapping the Bone Marrow Microenvironment – Investigators created a map of the stem cell niche in mouse bone marrow, and identified how it is influenced during healthy homeostasis and in leukemia.
Non-Invasive Tool Tracks Efficacy of Transplanted Stem Cells – Exosomes isolated from blood are a potential non-invasive method for monitoring the activity of transplanted cardiac progenitor cells following a heart attack.
Photo Reference: Courtesy of Dr. Bertie Göttgens