Dr. Ophir Klein is the inaugural Executive Director of Cedars-Sinai Guerin Children’s and the David and Meredith Kaplan Distinguished Chair in Children’s Health. He discusses his work on intestinal epithelium regeneration, which he will present at the “Tissue Fibrosis and Repair: Mechanism, Human Disease, and Therapies” Keystone Symposium taking place from June 12-16th in Keystone, Colorado. He also talks about mechanisms of tooth development, analyzing three-dimensional facial images to diagnose genetic syndromes, and how parasitic infections affect the intestinal stem cell niche.

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The Stem Cell Science Round Up

Zebrafish Skin Cell Division – Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.

Reducing Off-Target Effects of CAR T Therapy – Researchers developed a protease-based platform that uses an FDA-approved small molecule to regulate CAR activity.

Improving Hepatocyte Differentiation  – Thyroid hormone receptor beta was found to be a missing ingredient in lab-made liver cells.

Cellular Reprogramming Enhances Liver Regeneration – Liver-specific expression of the four Yamanaka factors indnduces cellular plasticity and counteracts liver failure in vivo.

Photo Reference: Courtesy of Dr. Ophir Klein