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Dr. Ophir Klein is the inaugural Executive Director of Cedars-Sinai Guerin Children’s and the David and Meredith Kaplan Distinguished Chair in Children’s Health. He discusses his work on intestinal epithelium regeneration, which he will present at the “Tissue Fibrosis and Repair: Mechanism, Human Disease, and Therapies” Keystone Symposium taking place from June 12-16th in Keystone, Colorado. He also talks about mechanisms of tooth development, analyzing three-dimensional facial images to diagnose genetic syndromes, and how parasitic infections affect the intestinal stem cell niche.
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Dr. Vivian Li is Group Leader of the Stem Cell and Cancer Biology Laboratory at the Francis Crick Institute. The Li lab investigates how Wnt signalling controls stem cells in the healthy gut and during colorectal cancer development. The lab also aims to engineer function intestinal constructs using patient-derived intestinal organoids.
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Dr. Henner Farin is a Young Investigator in the German Cancer Consortium, and a Junior Research Group Leader at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy. His group uses organoids to study cell signaling in intestinal stem cells and colorectal cancer.
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Dr. Hans Clevers from the Hubrecht Institute for Developmental Biology and Stem Cell Research is a pioneer in the field, studying the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells.
