Ep. 137: “Hematopoiesis and Cardiovascular Disease” Featuring Dr. Andrew Murphy
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Dr. Andrew Murphy is an Associate Professor at the Baker Heart and Diabetes Institute and Monash University in Melbourne, Australia. He seeks to understand the processes by which hematopoietic stem cells and the bone marrow niche become affected in disease, specifically in the context of cardiovascular and metabolic disease.
Resources and Links
Quiescence Increases the Resistance and Function of Old Neural Stem Cells – Increased quiescence makes aged neural stem cells resistant to regeneration. But, if activation is enforced, both young and old NSCs show similar proliferation and differentiation capacity.
A Gliogenic Switch for Human Astrocytes – Researchers have developed a new method to rapidly differentiate astrocytes from PSC-derived neural stem cells using a protein switch.
Generating Thalamic Organoids – Researchers have created thalamic organoids and fused them together with an organoid of the frontal cortex to study brain development and disease.
CRISPR Therapy for Hutchinson-Gilford Progeria Syndrome (Article 1)(Article 2) – Two separate research groups have used CRISPR to suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome.
CRISPR Makes iPSCs Invisible to the Immune System – Using CRISPR, scientists have created iPSCs that evade the immune system and prevent transplant rejection, poising them as a “universal” donor stem cell.
Photo Reference: Courtesy of Dr. Andrew Murphy